Biomaterial Database

Substance P elicits thromboxane-induced contraction of canine pulmonary veins. 1988

J A Russell

Department of Pediatrics, State University of New York, Buffalo 14214.

The effect of substance P on isolated rings of dog pulmonary vein was examined using tissue bath techniques. Substance P (10(-8)-10(-6) M) had no effect on baseline tone but equally potentiated matched contractions induced by exogenous norepinephrine (NE) and electrical field stimulation (ES). Potentiations produced by substance P were blocked by the substance P antagonist, [D-Arg, D-Pro2, D-Try, Leu] substance P as well as by indomethacin, the thromboxane synthetase inhibitor dazoxiben, and the thromboxane receptor antagonist SQ 29,548. Removal of the endothelium did not alter the substance P potentiation of NE-induced contractions but greatly enhanced the response to exogenous NE. There was marked desensitization to substance P but not to the thromboxane receptor agonist U-46619. We conclude that substance P enhances NE-induced contractions of pulmonary veins by stimulating the production and release of thromboxane A2 from non-endothelial cells. Thromboxane appears to exert a direct effect on smooth muscle cells rather than enhancing NE release from intramural neurons because the responses to NE and ES were potentiated equally. Desensitization probably resulted from down regulation of substance P receptors or depletion of thromboxane A2 rather than an effect on thromboxane A2 receptors.

UI	MeSH Term	Description	Entries
D009119	Muscle Contraction	A process leading to shortening and/or development of tension in muscle tissue. Muscle contraction occurs by a sliding filament mechanism whereby actin filaments slide inward among the myosin filaments.	Inotropism,Muscular Contraction,Contraction, Muscle,Contraction, Muscular,Contractions, Muscle,Contractions, Muscular,Inotropisms,Muscle Contractions,Muscular Contractions
D009131	Muscle, Smooth, Vascular	The nonstriated involuntary muscle tissue of blood vessels.	Vascular Smooth Muscle,Muscle, Vascular Smooth,Muscles, Vascular Smooth,Smooth Muscle, Vascular,Smooth Muscles, Vascular,Vascular Smooth Muscles
D011667	Pulmonary Veins	The veins that return the oxygenated blood from the lungs to the left atrium of the heart.	Pulmonary Vein,Vein, Pulmonary,Veins, Pulmonary
D004285	Dogs	The domestic dog, Canis familiaris, comprising about 400 breeds, of the carnivore family CANIDAE. They are worldwide in distribution and live in association with people. (Walker's Mammals of the World, 5th ed, p1065)	Canis familiaris,Dog
D000818	Animals	Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA.	Animal,Metazoa,Animalia
D013373	Substance P	An eleven-amino acid neurotransmitter that appears in both the central and peripheral nervous systems. It is involved in transmission of PAIN, causes rapid contractions of the gastrointestinal smooth muscle, and modulates inflammatory and immune responses.	Euler-Gaddum Substance P,Hypothalamic Substance P,SP(1-11),Euler Gaddum Substance P,Substance P, Euler-Gaddum,Substance P, Hypothalamic
D013928	Thromboxane A2	An unstable intermediate between the prostaglandin endoperoxides and thromboxane B2. The compound has a bicyclic oxaneoxetane structure. It is a potent inducer of platelet aggregation and causes vasoconstriction. It is the principal component of rabbit aorta contracting substance (RCS).	Rabbit Aorta Contracting Substance,A2, Thromboxane
D013931	Thromboxanes	Physiologically active compounds found in many organs of the body. They are formed in vivo from the prostaglandin endoperoxides and cause platelet aggregation, contraction of arteries, and other biological effects. Thromboxanes are important mediators of the actions of polyunsaturated fatty acids transformed by cyclooxygenase.	Thromboxane
D066298	In Vitro Techniques	Methods to study reactions or processes taking place in an artificial environment outside the living organism.	In Vitro Test,In Vitro Testing,In Vitro Tests,In Vitro as Topic,In Vitro,In Vitro Technique,In Vitro Testings,Technique, In Vitro,Techniques, In Vitro,Test, In Vitro,Testing, In Vitro,Testings, In Vitro,Tests, In Vitro,Vitro Testing, In