-transparent.png){kind=logo}
Synthesis and biological evaluation of chalcones as potential antileishmanial agents. 2014
Shweta Gupta, and
Rahul Shivahare, and
Venkateswarlu Korthikunta, and
Rohit Singh, and
Suman Gupta, and
Narender Tadigoppula
Division of Medicinal and Process Chemistry, CSIR-Central Drug Research Institute, Lucknow 226 031, India.
Antileishmanial activities of thirty-five synthetic chalcones have been examined. Among them, ten compounds (4, 6, 16, 22, 23, 24, 25, 29, 35 and 37) exhibited potent in vitro activity (IC50 range from 1.70 to 8 μM) against extracellular promastigotes and intracellular amastigotes form of Leishmania donovani. Two promising compounds 22 and 37 were tested in vivo in L. donovani/hamster model. Chalcone 37 showed 83.32% parasite inhibition at a dose of 50 mg/kg for 10 days whereas, 75.89% parasite inhibition at 100 mg/kg dose for 5 days by intraperitoneal route at day 7 post-treatment.
Related Publications
Shweta Gupta, and
Rahul Shivahare, and
Venkateswarlu Korthikunta, and
Rohit Singh, and
Suman Gupta, and
Narender Tadigoppula
June 2010,
Chemical biology & drug design,
Shweta Gupta, and
Rahul Shivahare, and
Venkateswarlu Korthikunta, and
Rohit Singh, and
Suman Gupta, and
Narender Tadigoppula
June 2005,
Bioorganic & medicinal chemistry letters,
Shweta Gupta, and
Rahul Shivahare, and
Venkateswarlu Korthikunta, and
Rohit Singh, and
Suman Gupta, and
Narender Tadigoppula
July 2010,
Bioorganic & medicinal chemistry letters,
Shweta Gupta, and
Rahul Shivahare, and
Venkateswarlu Korthikunta, and
Rohit Singh, and
Suman Gupta, and
Narender Tadigoppula
January 2010,
Bioorganic & medicinal chemistry,
Shweta Gupta, and
Rahul Shivahare, and
Venkateswarlu Korthikunta, and
Rohit Singh, and
Suman Gupta, and
Narender Tadigoppula
March 2024,
Archiv der Pharmazie,
Shweta Gupta, and
Rahul Shivahare, and
Venkateswarlu Korthikunta, and
Rohit Singh, and
Suman Gupta, and
Narender Tadigoppula
July 2009,
Archiv der Pharmazie,
Shweta Gupta, and
Rahul Shivahare, and
Venkateswarlu Korthikunta, and
Rohit Singh, and
Suman Gupta, and
Narender Tadigoppula
May 2011,
Bioorganic & medicinal chemistry,
Shweta Gupta, and
Rahul Shivahare, and
Venkateswarlu Korthikunta, and
Rohit Singh, and
Suman Gupta, and
Narender Tadigoppula
June 2014,
Bioorganic chemistry,
Shweta Gupta, and
Rahul Shivahare, and
Venkateswarlu Korthikunta, and
Rohit Singh, and
Suman Gupta, and
Narender Tadigoppula
January 2020,
Bioorganic chemistry,
Shweta Gupta, and
Rahul Shivahare, and
Venkateswarlu Korthikunta, and
Rohit Singh, and
Suman Gupta, and
Narender Tadigoppula
January 2015,
Medicinal chemistry (Shariqah (United Arab Emirates)),
