Glycyrrhizin inhibits traumatic brain injury by reducing HMGB1-RAGE interaction. 2014

Yu Okuma, and Keyue Liu, and Hidenori Wake, and Rui Liu, and Yoshito Nishimura, and Zhong Hui, and Kiyoshi Teshigawara, and Jun Haruma, and Yasuhiko Yamamoto, and Hiroshi Yamamoto, and Isao Date, and Hideo K Takahashi, and Shuji Mori, and Masahiro Nishibori
Department of Pharmacology, Okayama University Graduate School of Medicine, Dentistry & Pharmaceutical Sciences, 2-5-1 Shikata-cho, Kita-ku, Okayama 700-8558, Japan; Department of Neurosurgery, Okayama University Graduate School of Medicine, Dentistry & Pharmaceutical Sciences, 2-5-1 Shikata-cho, Kita-ku, Okayama 700-8558, Japan.

Glycyrrhizin (GL) is a major constituent of licorice root and has been suggested to inhibit the release of high mobility group box-1 (HMGB1), a protein considered representative of damage-associated molecular patterns. We found that GL bound HMGB1 but not RAGE with a moderate equilibrium dissociation constant value based on surface plasmon resonance analysis. This complex formation prevented HMGB1 from binding to RAGE in vitro. The effects of glycyrrhizin on traumatic brain injury (TBI) induced by fluid percussion were examined in rats or mice in the present study. GL was administered intravenously after TBI. Treatment of rats with GL dose-dependently suppressed the increase in BBB permeability and impairment of motor functions, in association with the inhibition of HMGB1 translocation in neurons in injured sites. The beneficial effects of GL on motor and cognitive functions persisted for 7 days after injury. The expression of TNF-α, IL-1β and IL-6 in injured sites was completely inhibited by GL treatment. In RAGE-/- mice, the effects of GL were not observed. These results suggested that GL may be a novel therapeutic agent for TBI through its interference with HMGB1 and RAGE interaction.

UI MeSH Term Description Entries
D008297 Male Males
D009043 Motor Activity Body movements of a human or an animal as a behavioral phenomenon. Activities, Motor,Activity, Motor,Motor Activities
D011897 Random Allocation A process involving chance used in therapeutic trials or other research endeavor for allocating experimental subjects, human or animal, between treatment and control groups, or among treatment groups. It may also apply to experiments on inanimate objects. Randomization,Allocation, Random
D011971 Receptors, Immunologic Cell surface molecules on cells of the immune system that specifically bind surface molecules or messenger molecules and trigger changes in the behavior of cells. Although these receptors were first identified in the immune system, many have important functions elsewhere. Immunologic Receptors,Immunologic Receptor,Immunological Receptors,Receptor, Immunologic,Receptors, Immunological
D001812 Blood-Brain Barrier Specialized non-fenestrated tightly-joined ENDOTHELIAL CELLS with TIGHT JUNCTIONS that form a transport barrier for certain substances between the cerebral capillaries and the BRAIN tissue. Brain-Blood Barrier,Hemato-Encephalic Barrier,Barrier, Blood-Brain,Barrier, Brain-Blood,Barrier, Hemato-Encephalic,Barriers, Blood-Brain,Barriers, Brain-Blood,Barriers, Hemato-Encephalic,Blood Brain Barrier,Blood-Brain Barriers,Brain Blood Barrier,Brain-Blood Barriers,Hemato Encephalic Barrier,Hemato-Encephalic Barriers
D001921 Brain The part of CENTRAL NERVOUS SYSTEM that is contained within the skull (CRANIUM). Arising from the NEURAL TUBE, the embryonic brain is comprised of three major parts including PROSENCEPHALON (the forebrain); MESENCEPHALON (the midbrain); and RHOMBENCEPHALON (the hindbrain). The developed brain consists of CEREBRUM; CEREBELLUM; and other structures in the BRAIN STEM. Encephalon
D001929 Brain Edema Increased intracellular or extracellular fluid in brain tissue. Cytotoxic brain edema (swelling due to increased intracellular fluid) is indicative of a disturbance in cell metabolism, and is commonly associated with hypoxic or ischemic injuries (see HYPOXIA, BRAIN). An increase in extracellular fluid may be caused by increased brain capillary permeability (vasogenic edema), an osmotic gradient, local blockages in interstitial fluid pathways, or by obstruction of CSF flow (e.g., obstructive HYDROCEPHALUS). (From Childs Nerv Syst 1992 Sep; 8(6):301-6) Brain Swelling,Cerebral Edema,Cytotoxic Brain Edema,Intracranial Edema,Vasogenic Cerebral Edema,Cerebral Edema, Cytotoxic,Cerebral Edema, Vasogenic,Cytotoxic Cerebral Edema,Vasogenic Brain Edema,Brain Edema, Cytotoxic,Brain Edema, Vasogenic,Brain Swellings,Cerebral Edemas, Vasogenic,Edema, Brain,Edema, Cerebral,Edema, Cytotoxic Brain,Edema, Cytotoxic Cerebral,Edema, Intracranial,Edema, Vasogenic Brain,Edema, Vasogenic Cerebral,Swelling, Brain
D001930 Brain Injuries Acute and chronic (see also BRAIN INJURIES, CHRONIC) injuries to the brain, including the cerebral hemispheres, CEREBELLUM, and BRAIN STEM. Clinical manifestations depend on the nature of injury. Diffuse trauma to the brain is frequently associated with DIFFUSE AXONAL INJURY or COMA, POST-TRAUMATIC. Localized injuries may be associated with NEUROBEHAVIORAL MANIFESTATIONS; HEMIPARESIS, or other focal neurologic deficits. Brain Lacerations,Acute Brain Injuries,Brain Injuries, Acute,Brain Injuries, Focal,Focal Brain Injuries,Injuries, Acute Brain,Injuries, Brain,Acute Brain Injury,Brain Injury,Brain Injury, Acute,Brain Injury, Focal,Brain Laceration,Focal Brain Injury,Injuries, Focal Brain,Injury, Acute Brain,Injury, Brain,Injury, Focal Brain,Laceration, Brain,Lacerations, Brain
D002199 Capillary Permeability The property of blood capillary ENDOTHELIUM that allows for the selective exchange of substances between the blood and surrounding tissues and through membranous barriers such as the BLOOD-AIR BARRIER; BLOOD-AQUEOUS BARRIER; BLOOD-BRAIN BARRIER; BLOOD-NERVE BARRIER; BLOOD-RETINAL BARRIER; and BLOOD-TESTIS BARRIER. Small lipid-soluble molecules such as carbon dioxide and oxygen move freely by diffusion. Water and water-soluble molecules cannot pass through the endothelial walls and are dependent on microscopic pores. These pores show narrow areas (TIGHT JUNCTIONS) which may limit large molecule movement. Microvascular Permeability,Permeability, Capillary,Permeability, Microvascular,Vascular Permeability,Capillary Permeabilities,Microvascular Permeabilities,Permeabilities, Capillary,Permeabilities, Microvascular,Permeabilities, Vascular,Permeability, Vascular,Vascular Permeabilities
D003071 Cognition Intellectual or mental process whereby an organism obtains knowledge. Cognitive Function,Cognitions,Cognitive Functions,Function, Cognitive,Functions, Cognitive

Related Publications

Yu Okuma, and Keyue Liu, and Hidenori Wake, and Rui Liu, and Yoshito Nishimura, and Zhong Hui, and Kiyoshi Teshigawara, and Jun Haruma, and Yasuhiko Yamamoto, and Hiroshi Yamamoto, and Isao Date, and Hideo K Takahashi, and Shuji Mori, and Masahiro Nishibori
March 2012, The journal of trauma and acute care surgery,
Yu Okuma, and Keyue Liu, and Hidenori Wake, and Rui Liu, and Yoshito Nishimura, and Zhong Hui, and Kiyoshi Teshigawara, and Jun Haruma, and Yasuhiko Yamamoto, and Hiroshi Yamamoto, and Isao Date, and Hideo K Takahashi, and Shuji Mori, and Masahiro Nishibori
September 2012, The journal of trauma and acute care surgery,
Yu Okuma, and Keyue Liu, and Hidenori Wake, and Rui Liu, and Yoshito Nishimura, and Zhong Hui, and Kiyoshi Teshigawara, and Jun Haruma, and Yasuhiko Yamamoto, and Hiroshi Yamamoto, and Isao Date, and Hideo K Takahashi, and Shuji Mori, and Masahiro Nishibori
September 2014, Science translational medicine,
Yu Okuma, and Keyue Liu, and Hidenori Wake, and Rui Liu, and Yoshito Nishimura, and Zhong Hui, and Kiyoshi Teshigawara, and Jun Haruma, and Yasuhiko Yamamoto, and Hiroshi Yamamoto, and Isao Date, and Hideo K Takahashi, and Shuji Mori, and Masahiro Nishibori
September 2019, International journal of molecular medicine,
Yu Okuma, and Keyue Liu, and Hidenori Wake, and Rui Liu, and Yoshito Nishimura, and Zhong Hui, and Kiyoshi Teshigawara, and Jun Haruma, and Yasuhiko Yamamoto, and Hiroshi Yamamoto, and Isao Date, and Hideo K Takahashi, and Shuji Mori, and Masahiro Nishibori
September 2014, Science translational medicine,
Yu Okuma, and Keyue Liu, and Hidenori Wake, and Rui Liu, and Yoshito Nishimura, and Zhong Hui, and Kiyoshi Teshigawara, and Jun Haruma, and Yasuhiko Yamamoto, and Hiroshi Yamamoto, and Isao Date, and Hideo K Takahashi, and Shuji Mori, and Masahiro Nishibori
February 2022, Journal of cellular and molecular medicine,
Yu Okuma, and Keyue Liu, and Hidenori Wake, and Rui Liu, and Yoshito Nishimura, and Zhong Hui, and Kiyoshi Teshigawara, and Jun Haruma, and Yasuhiko Yamamoto, and Hiroshi Yamamoto, and Isao Date, and Hideo K Takahashi, and Shuji Mori, and Masahiro Nishibori
October 2020, Brain sciences,
Yu Okuma, and Keyue Liu, and Hidenori Wake, and Rui Liu, and Yoshito Nishimura, and Zhong Hui, and Kiyoshi Teshigawara, and Jun Haruma, and Yasuhiko Yamamoto, and Hiroshi Yamamoto, and Isao Date, and Hideo K Takahashi, and Shuji Mori, and Masahiro Nishibori
December 2015, Antioxidants & redox signaling,
Yu Okuma, and Keyue Liu, and Hidenori Wake, and Rui Liu, and Yoshito Nishimura, and Zhong Hui, and Kiyoshi Teshigawara, and Jun Haruma, and Yasuhiko Yamamoto, and Hiroshi Yamamoto, and Isao Date, and Hideo K Takahashi, and Shuji Mori, and Masahiro Nishibori
January 2021, Translational neuroscience,
Yu Okuma, and Keyue Liu, and Hidenori Wake, and Rui Liu, and Yoshito Nishimura, and Zhong Hui, and Kiyoshi Teshigawara, and Jun Haruma, and Yasuhiko Yamamoto, and Hiroshi Yamamoto, and Isao Date, and Hideo K Takahashi, and Shuji Mori, and Masahiro Nishibori
March 2018, European review for medical and pharmacological sciences,
Copied contents to your clipboard!