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Immunomagnetic T-lymphocyte depletion (ITLD) of rat bone marrow using OX-19 monoclonal antibody. 1989
A L Hoffman, and
L Makowka, and
D V Cramer, and
X Cai, and
A Pascualone, and
B F Banner, and
D G Sheahan, and
P Rettinger, and
T E Starzl
Department of Surgery, University of Pittsburgh School of Medicine, PA 15261.
Graft versus host disease (GVHD) may be abrogated and host survival prolonged by in vitro depletion of T lymphocytes from bone marrow (BM) prior to allotransplantation. Using a mouse anti-rat pan T-lymphocyte monoclonal antibody (OX19) bound to monosized, magnetic, polymer beads, T lymphocytes were removed in vitro from normal bone marrow. The removal of the T lymphocytes was confirmed by flow cytometry. Injection of the T-lymphocyte-depleted bone marrow into fully allogeneic rats prevents the induction of GVHD and prolongs host survival.
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D G Sheahan, and
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A L Hoffman, and
L Makowka, and
D V Cramer, and
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P Rettinger, and
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Journal of hematotherapy,
A L Hoffman, and
L Makowka, and
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B F Banner, and
D G Sheahan, and
P Rettinger, and
T E Starzl
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L Makowka, and
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X Cai, and
A Pascualone, and
B F Banner, and
D G Sheahan, and
P Rettinger, and
T E Starzl
June 1984,
Immunology,
A L Hoffman, and
L Makowka, and
D V Cramer, and
X Cai, and
A Pascualone, and
B F Banner, and
D G Sheahan, and
P Rettinger, and
T E Starzl
March 1984,
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