-transparent.png){kind=logo}
We constructed transgenic mice that carry the cDNA of human interleukin-2 (IL-2) under the control of the H-2Kd promoter. The IL-2 transgenic mice expressed human IL-2 mRNA in the thymus, spleen, bone marrow, lung, muscle and skin. Human IL-2 protein was also detected in their sera. The IL-2 transgenic mice suffered from alopecia and pneumonia, but no typical autoimmune reactions seemed to be involved in these lesions. In the epidermis of the IL-2 transgenic mice there was an increase in Thy-1+ dendritic epidermal cells (DEC), which might be involved in the skin lesion. Immune responses of their spleen cells against antigens were significantly impaired whereas their spleen cells responded well to polyclonal lymphocyte activators.
Y Ishida, and
M Nishi, and
O Taguchi, and
K Inaba, and
N Minato, and
M Kawaichi, and
T Honjo
July 1990,
The Tokai journal of experimental and clinical medicine,
Y Ishida, and
M Nishi, and
O Taguchi, and
K Inaba, and
N Minato, and
M Kawaichi, and
T Honjo
January 1987,
Nature,
Y Ishida, and
M Nishi, and
O Taguchi, and
K Inaba, and
N Minato, and
M Kawaichi, and
T Honjo
January 1993,
Archives of dermatological research,
Y Ishida, and
M Nishi, and
O Taguchi, and
K Inaba, and
N Minato, and
M Kawaichi, and
T Honjo
June 2003,
Journal of biotechnology,
Y Ishida, and
M Nishi, and
O Taguchi, and
K Inaba, and
N Minato, and
M Kawaichi, and
T Honjo
June 1995,
Science (New York, N.Y.),
Y Ishida, and
M Nishi, and
O Taguchi, and
K Inaba, and
N Minato, and
M Kawaichi, and
T Honjo
September 1996,
The Journal of biological chemistry,
Y Ishida, and
M Nishi, and
O Taguchi, and
K Inaba, and
N Minato, and
M Kawaichi, and
T Honjo
January 1988,
Current topics in microbiology and immunology,
Y Ishida, and
M Nishi, and
O Taguchi, and
K Inaba, and
N Minato, and
M Kawaichi, and
T Honjo
January 2001,
Archivum immunologiae et therapiae experimentalis,
Y Ishida, and
M Nishi, and
O Taguchi, and
K Inaba, and
N Minato, and
M Kawaichi, and
T Honjo
December 2001,
Journal of cardiac failure,
Y Ishida, and
M Nishi, and
O Taguchi, and
K Inaba, and
N Minato, and
M Kawaichi, and
T Honjo
December 1993,
Journal of virology,
