Biomaterial Database

Kaposi's sarcoma in AIDS. 1989

P A Volberding

School of Medicine, University of California, San Francisco.

Because Kaposi's sarcoma is a highly visible disease and one readily confirmed histologically, it continues to play an important role in the clinical spectrum of AIDS. At this time, it can not be confirmed whether AIDS-related Kaposi's sarcoma is caused by an initial viral infection, whether the development of an immune deficiency predisposes patients to develop this malignancy, or whether viral or other cofactors may be involved. Evaluation of therapies for AIDS-related Kaposi's sarcoma is made more difficult by the lack of natural history information. In addition, available drugs are often immunosuppressing and investigators have considerable concern in utilizing these therapies to treat Kaposi's sarcoma, a cancer that is intimately associated with immune deficiency. Extensive research continues on single-agent trials of cytotoxic agents as well as immune modulators and antiviral agents. Although considerable progress has been made in the treatment of AIDS-related Kaposi's sarcoma, therapeutic decision-making is extremely difficult. It is expected that additional trials and experimental agents will improve our ability to provide effective treatment.

UI	MeSH Term	Description	Entries
D006801	Humans	Members of the species Homo sapiens.	Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D000163	Acquired Immunodeficiency Syndrome	An acquired defect of cellular immunity associated with infection by the human immunodeficiency virus (HIV), a CD4-positive T-lymphocyte count under 200 cells/microliter or less than 14% of total lymphocytes, and increased susceptibility to opportunistic infections and malignant neoplasms. Clinical manifestations also include emaciation (wasting) and dementia. These elements reflect criteria for AIDS as defined by the CDC in 1993.	AIDS,Immunodeficiency Syndrome, Acquired,Immunologic Deficiency Syndrome, Acquired,Acquired Immune Deficiency Syndrome,Acquired Immuno-Deficiency Syndrome,Acquired Immuno Deficiency Syndrome,Acquired Immuno-Deficiency Syndromes,Acquired Immunodeficiency Syndromes,Immuno-Deficiency Syndrome, Acquired,Immuno-Deficiency Syndromes, Acquired,Immunodeficiency Syndromes, Acquired,Syndrome, Acquired Immuno-Deficiency,Syndrome, Acquired Immunodeficiency,Syndromes, Acquired Immuno-Deficiency,Syndromes, Acquired Immunodeficiency
D012514	Sarcoma, Kaposi	A multicentric, malignant neoplastic vascular proliferation characterized by the development of bluish-red cutaneous nodules, usually on the lower extremities, most often on the toes or feet, and slowly increasing in size and number and spreading to more proximal areas. The tumors have endothelium-lined channels and vascular spaces admixed with variably sized aggregates of spindle-shaped cells, and often remain confined to the skin and subcutaneous tissue, but widespread visceral involvement may occur. Kaposi's sarcoma occurs spontaneously in Jewish and Italian males in Europe and the United States. An aggressive variant in young children is endemic in some areas of Africa. A third form occurs in about 0.04% of kidney transplant patients. There is also a high incidence in AIDS patients. (From Dorland, 27th ed & Holland et al., Cancer Medicine, 3d ed, pp2105-7) HHV-8 is the suspected cause.	Kaposi Sarcoma,Kaposi's Sarcoma,Multiple Idiopathic Pigmented Hemangiosarcoma,Kaposis Sarcoma,Sarcoma, Kaposi's

Related Publications

P A Volberding

[Kaposi's sarcoma in AIDS].

October 1985, Tidsskrift for den Norske laegeforening : tidsskrift for praktisk medicin, ny raekke,

P A Volberding

[Kaposi's sarcoma in AIDS].

September 1993, Nihon rinsho. Japanese journal of clinical medicine,

P A Volberding

[Oral Kaposi's sarcoma (AIDS). X-ray findings in oral Kaposi's sarcoma (AIDS)].

January 1989, Schweizer Monatsschrift fur Zahnmedizin = Revue mensuelle suisse d'odonto-stomatologie = Rivista mensile svizzera di odontologia e stomatologia,

P A Volberding

AIDS-related Kaposi's sarcoma.

July 1992, International journal of dermatology,

P A Volberding

Kaposi's sarcoma and AIDS.

August 1990, Nature,

P A Volberding

AIDS-associated Kaposi's sarcoma.

December 1987, Journal of the American Dental Association (1939),

P A Volberding

Kaposi's sarcoma/AIDS cofactors.

November 1989, International journal of dermatology,