-transparent.png){kind=logo}
Discovery of MK-7725, A Potent, Selective Bombesin Receptor Subtype-3 Agonist for the Treatment of Obesity. 2012
Harry R Chobanian, and
Yan Guo, and
Ping Liu, and
Marc Chioda, and
Thomas J Lanza, and
Linda Chang, and
Theresa M Kelly, and
Yanqing Kan, and
Oksana Palyha, and
Xiao-Ming Guan, and
Donald J Marsh, and
Joseph M Metzger, and
Judith N Gorski, and
Kate Raustad, and
Sheng-Ping Wang, and
Alison M Strack, and
Randy Miller, and
Jianmei Pang, and
Maria Madeira, and
Kathy Lyons, and
Jasminka Dragovic, and
Marc L Reitman, and
Ravi P Nargund, and
Linus S Lin
Departments of Medicinal Chemistry, Metabolic Disorders, Pharmacology, and Drug Metabolism, Merck Research Laboratories , Rahway, New Jersey 07065, United States.
Extensive structure-activity relationship studies of a series derived from atropisomer 1, a previously described chiral benzodiazepine sulfonamide series, led to a potent, brain penetrant and selective compound with excellent preclinical pharmacokinetic across species. We also describe the utilization of a high throughput mouse pharmacodynamic assay which allowed for expedient assessment of pharmacokinetic and brain distribution.
| UI | MeSH Term | Description | Entries |
|---|
Related Publications
Harry R Chobanian, and
Yan Guo, and
Ping Liu, and
Marc Chioda, and
Thomas J Lanza, and
Linda Chang, and
Theresa M Kelly, and
Yanqing Kan, and
Oksana Palyha, and
Xiao-Ming Guan, and
Donald J Marsh, and
Joseph M Metzger, and
Judith N Gorski, and
Kate Raustad, and
Sheng-Ping Wang, and
Alison M Strack, and
Randy Miller, and
Jianmei Pang, and
Maria Madeira, and
Kathy Lyons, and
Jasminka Dragovic, and
Marc L Reitman, and
Ravi P Nargund, and
Linus S Lin
January 2011,
ACS medicinal chemistry letters,
Harry R Chobanian, and
Yan Guo, and
Ping Liu, and
Marc Chioda, and
Thomas J Lanza, and
Linda Chang, and
Theresa M Kelly, and
Yanqing Kan, and
Oksana Palyha, and
Xiao-Ming Guan, and
Donald J Marsh, and
Joseph M Metzger, and
Judith N Gorski, and
Kate Raustad, and
Sheng-Ping Wang, and
Alison M Strack, and
Randy Miller, and
Jianmei Pang, and
Maria Madeira, and
Kathy Lyons, and
Jasminka Dragovic, and
Marc L Reitman, and
Ravi P Nargund, and
Linus S Lin
June 2023,
Journal of medicinal chemistry,
Harry R Chobanian, and
Yan Guo, and
Ping Liu, and
Marc Chioda, and
Thomas J Lanza, and
Linda Chang, and
Theresa M Kelly, and
Yanqing Kan, and
Oksana Palyha, and
Xiao-Ming Guan, and
Donald J Marsh, and
Joseph M Metzger, and
Judith N Gorski, and
Kate Raustad, and
Sheng-Ping Wang, and
Alison M Strack, and
Randy Miller, and
Jianmei Pang, and
Maria Madeira, and
Kathy Lyons, and
Jasminka Dragovic, and
Marc L Reitman, and
Ravi P Nargund, and
Linus S Lin
February 2011,
The Journal of pharmacology and experimental therapeutics,
Harry R Chobanian, and
Yan Guo, and
Ping Liu, and
Marc Chioda, and
Thomas J Lanza, and
Linda Chang, and
Theresa M Kelly, and
Yanqing Kan, and
Oksana Palyha, and
Xiao-Ming Guan, and
Donald J Marsh, and
Joseph M Metzger, and
Judith N Gorski, and
Kate Raustad, and
Sheng-Ping Wang, and
Alison M Strack, and
Randy Miller, and
Jianmei Pang, and
Maria Madeira, and
Kathy Lyons, and
Jasminka Dragovic, and
Marc L Reitman, and
Ravi P Nargund, and
Linus S Lin
September 2009,
Biochemical and biophysical research communications,
Harry R Chobanian, and
Yan Guo, and
Ping Liu, and
Marc Chioda, and
Thomas J Lanza, and
Linda Chang, and
Theresa M Kelly, and
Yanqing Kan, and
Oksana Palyha, and
Xiao-Ming Guan, and
Donald J Marsh, and
Joseph M Metzger, and
Judith N Gorski, and
Kate Raustad, and
Sheng-Ping Wang, and
Alison M Strack, and
Randy Miller, and
Jianmei Pang, and
Maria Madeira, and
Kathy Lyons, and
Jasminka Dragovic, and
Marc L Reitman, and
Ravi P Nargund, and
Linus S Lin
August 2022,
The Journal of pharmacology and experimental therapeutics,
Harry R Chobanian, and
Yan Guo, and
Ping Liu, and
Marc Chioda, and
Thomas J Lanza, and
Linda Chang, and
Theresa M Kelly, and
Yanqing Kan, and
Oksana Palyha, and
Xiao-Ming Guan, and
Donald J Marsh, and
Joseph M Metzger, and
Judith N Gorski, and
Kate Raustad, and
Sheng-Ping Wang, and
Alison M Strack, and
Randy Miller, and
Jianmei Pang, and
Maria Madeira, and
Kathy Lyons, and
Jasminka Dragovic, and
Marc L Reitman, and
Ravi P Nargund, and
Linus S Lin
February 2010,
Cell metabolism,
Harry R Chobanian, and
Yan Guo, and
Ping Liu, and
Marc Chioda, and
Thomas J Lanza, and
Linda Chang, and
Theresa M Kelly, and
Yanqing Kan, and
Oksana Palyha, and
Xiao-Ming Guan, and
Donald J Marsh, and
Joseph M Metzger, and
Judith N Gorski, and
Kate Raustad, and
Sheng-Ping Wang, and
Alison M Strack, and
Randy Miller, and
Jianmei Pang, and
Maria Madeira, and
Kathy Lyons, and
Jasminka Dragovic, and
Marc L Reitman, and
Ravi P Nargund, and
Linus S Lin
September 2012,
Journal of clinical pharmacology,
Harry R Chobanian, and
Yan Guo, and
Ping Liu, and
Marc Chioda, and
Thomas J Lanza, and
Linda Chang, and
Theresa M Kelly, and
Yanqing Kan, and
Oksana Palyha, and
Xiao-Ming Guan, and
Donald J Marsh, and
Joseph M Metzger, and
Judith N Gorski, and
Kate Raustad, and
Sheng-Ping Wang, and
Alison M Strack, and
Randy Miller, and
Jianmei Pang, and
Maria Madeira, and
Kathy Lyons, and
Jasminka Dragovic, and
Marc L Reitman, and
Ravi P Nargund, and
Linus S Lin
October 2013,
The Journal of pharmacology and experimental therapeutics,
Harry R Chobanian, and
Yan Guo, and
Ping Liu, and
Marc Chioda, and
Thomas J Lanza, and
Linda Chang, and
Theresa M Kelly, and
Yanqing Kan, and
Oksana Palyha, and
Xiao-Ming Guan, and
Donald J Marsh, and
Joseph M Metzger, and
Judith N Gorski, and
Kate Raustad, and
Sheng-Ping Wang, and
Alison M Strack, and
Randy Miller, and
Jianmei Pang, and
Maria Madeira, and
Kathy Lyons, and
Jasminka Dragovic, and
Marc L Reitman, and
Ravi P Nargund, and
Linus S Lin
March 2010,
Bioorganic & medicinal chemistry letters,
Harry R Chobanian, and
Yan Guo, and
Ping Liu, and
Marc Chioda, and
Thomas J Lanza, and
Linda Chang, and
Theresa M Kelly, and
Yanqing Kan, and
Oksana Palyha, and
Xiao-Ming Guan, and
Donald J Marsh, and
Joseph M Metzger, and
Judith N Gorski, and
Kate Raustad, and
Sheng-Ping Wang, and
Alison M Strack, and
Randy Miller, and
Jianmei Pang, and
Maria Madeira, and
Kathy Lyons, and
Jasminka Dragovic, and
Marc L Reitman, and
Ravi P Nargund, and
Linus S Lin
March 2005,
Journal of peptide science : an official publication of the European Peptide Society,
