Analytical findings of an acute intoxication after inhalation of methoxetamine. 2014

Laurent Imbert, and Alexandra Boucher, and Gilles Delhome, and Thierry Cueto, and Michel Boudinaud, and Julie Maublanc, and Sylvain Dulaurent, and Jacques Descotes, and Gérard Lachâtre, and Jean-Michel Gaulier
Department of Pharmacology and Toxicology, University Hospital, Limoges 87042, France laurent.imbert@ch-havre.fr.

Methoxetamine (MXE) is increasingly used and abused, as it is frequently presented as being safer than ketamine, and legal. Cases of only MXE consumption being associated with the occurrence of seizures are rarely reported. A single MXE intoxication case by inhalation is described concerning a 21-year-old man, not known to be epileptic, who was found collapsed in his bedroom, supposedly after an epileptic seizure. He was transferred to the Emergency Department of the Henri Mondor Hospital, Aurillac, France. He was conscious, but with a sinus bradycardia (48/min) and an ST-segment elevation on the electrocardiogram, and a slightly increased creatine kinase level (270 U/L) and hyponatremia (127 mmol/L). New seizure activity occurred during hospitalization, but the clinical course in the intensive care unit was favorable. Quantitation of MXE in serum and urine using gas chromatography coupled to mass spectrometry (GC-MS) was developed, as well as a liquid chromatography coupled to tandem mass spectrometry (LC-MS-MS) method for the determination of MXE in hair. Limits of detection and quantification were, respectively, 2 and 10 µg/L for the GC-MS method and both 0.5 pg/mg for the LC-MS-MS method. Concentrations of 30 and 408 µg/L were, respectively, measured in serum and urine. Concentrations of 135 and 145 pg/mg were detected in two 2.5 cm hair strands, consistent with one or several consumptions during the 2 ½ months prior to sampling. A sample of the powder consumed was available and also analyzed. This case illustrates the dangers of this drug, which justify its classification as a narcotic in France since August 2013.

UI MeSH Term Description Entries
D008297 Male Males
D008401 Gas Chromatography-Mass Spectrometry A microanalytical technique combining mass spectrometry and gas chromatography for the qualitative as well as quantitative determinations of compounds. Chromatography, Gas-Liquid-Mass Spectrometry,Chromatography, Gas-Mass Spectrometry,GCMS,Spectrometry, Mass-Gas Chromatography,Spectrum Analysis, Mass-Gas Chromatography,Gas-Liquid Chromatography-Mass Spectrometry,Mass Spectrometry-Gas Chromatography,Chromatography, Gas Liquid Mass Spectrometry,Chromatography, Gas Mass Spectrometry,Chromatography, Mass Spectrometry-Gas,Chromatography-Mass Spectrometry, Gas,Chromatography-Mass Spectrometry, Gas-Liquid,Gas Chromatography Mass Spectrometry,Gas Liquid Chromatography Mass Spectrometry,Mass Spectrometry Gas Chromatography,Spectrometries, Mass-Gas Chromatography,Spectrometry, Gas Chromatography-Mass,Spectrometry, Gas-Liquid Chromatography-Mass,Spectrometry, Mass Gas Chromatography,Spectrometry-Gas Chromatography, Mass,Spectrum Analysis, Mass Gas Chromatography
D003512 Cyclohexanones Cyclohexane ring substituted by one or more ketones in any position.
D003514 Cyclohexylamines A family of alicyclic hydrocarbons containing an amine group with the general formula R-C6H10NH2. Cyclohexylamine
D006197 Hair A filament-like structure consisting of a shaft which projects to the surface of the SKIN from a root which is softer than the shaft and lodges in the cavity of a HAIR FOLLICLE. It is found on most surfaces of the body. Fetal Hair,Hair, Fetal,Lanugo,Fetal Hairs,Hairs,Hairs, Fetal
D006801 Humans Members of the species Homo sapiens. Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D012640 Seizures Clinical or subclinical disturbances of cortical function due to a sudden, abnormal, excessive, and disorganized discharge of brain cells. Clinical manifestations include abnormal motor, sensory and psychic phenomena. Recurrent seizures are usually referred to as EPILEPSY or "seizure disorder." Absence Seizure,Absence Seizures,Atonic Absence Seizure,Atonic Seizure,Clonic Seizure,Complex Partial Seizure,Convulsion,Convulsions,Convulsive Seizure,Convulsive Seizures,Epileptic Seizure,Epileptic Seizures,Generalized Absence Seizure,Generalized Tonic-Clonic Seizures,Jacksonian Seizure,Myoclonic Seizure,Non-Epileptic Seizure,Nonepileptic Seizure,Partial Seizure,Seizure,Seizures, Convulsive,Seizures, Focal,Seizures, Generalized,Seizures, Motor,Seizures, Sensory,Tonic Clonic Seizure,Tonic Seizure,Tonic-Clonic Seizure,Atonic Absence Seizures,Atonic Seizures,Clonic Seizures,Complex Partial Seizures,Convulsion, Non-Epileptic,Generalized Absence Seizures,Myoclonic Seizures,Non-Epileptic Seizures,Nonepileptic Seizures,Partial Seizures,Petit Mal Convulsion,Seizures, Auditory,Seizures, Clonic,Seizures, Epileptic,Seizures, Gustatory,Seizures, Olfactory,Seizures, Somatosensory,Seizures, Tonic,Seizures, Tonic-Clonic,Seizures, Vertiginous,Seizures, Vestibular,Seizures, Visual,Single Seizure,Tonic Seizures,Tonic-Clonic Seizures,Absence Seizure, Atonic,Absence Seizure, Generalized,Absence Seizures, Atonic,Absence Seizures, Generalized,Auditory Seizure,Auditory Seizures,Clonic Seizure, Tonic,Clonic Seizures, Tonic,Convulsion, Non Epileptic,Convulsion, Petit Mal,Convulsions, Non-Epileptic,Focal Seizure,Focal Seizures,Generalized Seizure,Generalized Seizures,Generalized Tonic Clonic Seizures,Generalized Tonic-Clonic Seizure,Gustatory Seizure,Gustatory Seizures,Motor Seizure,Motor Seizures,Non Epileptic Seizure,Non Epileptic Seizures,Non-Epileptic Convulsion,Non-Epileptic Convulsions,Olfactory Seizure,Olfactory Seizures,Partial Seizure, Complex,Partial Seizures, Complex,Seizure, Absence,Seizure, Atonic,Seizure, Atonic Absence,Seizure, Auditory,Seizure, Clonic,Seizure, Complex Partial,Seizure, Convulsive,Seizure, Epileptic,Seizure, Focal,Seizure, Generalized,Seizure, Generalized Absence,Seizure, Generalized Tonic-Clonic,Seizure, Gustatory,Seizure, Jacksonian,Seizure, Motor,Seizure, Myoclonic,Seizure, Non-Epileptic,Seizure, Nonepileptic,Seizure, Olfactory,Seizure, Partial,Seizure, Sensory,Seizure, Single,Seizure, Somatosensory,Seizure, Tonic,Seizure, Tonic Clonic,Seizure, Tonic-Clonic,Seizure, Vertiginous,Seizure, Vestibular,Seizure, Visual,Seizures, Generalized Tonic-Clonic,Seizures, Nonepileptic,Sensory Seizure,Sensory Seizures,Single Seizures,Somatosensory Seizure,Somatosensory Seizures,Tonic Clonic Seizures,Tonic-Clonic Seizure, Generalized,Tonic-Clonic Seizures, Generalized,Vertiginous Seizure,Vertiginous Seizures,Vestibular Seizure,Vestibular Seizures,Visual Seizure,Visual Seizures
D013287 Illicit Drugs Drugs that are manufactured, obtained, or sold illegally. They include prescription drugs obtained or sold without prescription and non-prescription drugs. Illicit drugs are widely distributed, tend to be grossly impure and may cause unexpected toxicity. Club Drug,Drugs, Illegal,Illegal Drug,Illegal Drugs,Illicit Drug,Recreational Drug,Recreational Drugs,Street Drug,Street Drugs,Club Drugs,Drug, Club,Drug, Illegal,Drug, Illicit,Drug, Recreational,Drug, Street,Drugs, Club,Drugs, Illicit,Drugs, Recreational,Drugs, Street
D015203 Reproducibility of Results The statistical reproducibility of measurements (often in a clinical context), including the testing of instrumentation or techniques to obtain reproducible results. The concept includes reproducibility of physiological measurements, which may be used to develop rules to assess probability or prognosis, or response to a stimulus; reproducibility of occurrence of a condition; and reproducibility of experimental results. Reliability and Validity,Reliability of Result,Reproducibility Of Result,Reproducibility of Finding,Validity of Result,Validity of Results,Face Validity,Reliability (Epidemiology),Reliability of Results,Reproducibility of Findings,Test-Retest Reliability,Validity (Epidemiology),Finding Reproducibilities,Finding Reproducibility,Of Result, Reproducibility,Of Results, Reproducibility,Reliabilities, Test-Retest,Reliability, Test-Retest,Result Reliabilities,Result Reliability,Result Validities,Result Validity,Result, Reproducibility Of,Results, Reproducibility Of,Test Retest Reliability,Validity and Reliability,Validity, Face
D015813 Substance Abuse Detection Detection of drugs that have been abused, overused, or misused, including legal and illegal drugs. Urine screening is the usual method of detection. Drug Abuse Testing,Illicit Drug Testing,Street Drug Testing,Substance Abuse Testing,Drug Abuse Detection,Drug Abuse Screening,Illicit Drug Detection,Street Drug Detection,Detection, Drug Abuse,Detection, Illicit Drug,Detection, Street Drug,Detection, Substance Abuse,Detections, Drug Abuse,Detections, Illicit Drug,Detections, Street Drug,Detections, Substance Abuse,Drug Abuse Detections,Drug Abuse Screenings,Drug Abuse Testings,Drug Testing, Illicit,Drug Testings, Illicit,Illicit Drug Detections,Illicit Drug Testings,Screening, Drug Abuse,Screenings, Drug Abuse,Street Drug Detections,Street Drug Testings,Substance Abuse Detections,Substance Abuse Testings,Testing, Drug Abuse,Testing, Illicit Drug,Testing, Street Drug,Testing, Substance Abuse,Testings, Drug Abuse,Testings, Illicit Drug,Testings, Street Drug,Testings, Substance Abuse

Related Publications

Laurent Imbert, and Alexandra Boucher, and Gilles Delhome, and Thierry Cueto, and Michel Boudinaud, and Julie Maublanc, and Sylvain Dulaurent, and Jacques Descotes, and Gérard Lachâtre, and Jean-Michel Gaulier
January 2013, Journal of analytical toxicology,
Laurent Imbert, and Alexandra Boucher, and Gilles Delhome, and Thierry Cueto, and Michel Boudinaud, and Julie Maublanc, and Sylvain Dulaurent, and Jacques Descotes, and Gérard Lachâtre, and Jean-Michel Gaulier
January 2015, Journal of forensic sciences,
Laurent Imbert, and Alexandra Boucher, and Gilles Delhome, and Thierry Cueto, and Michel Boudinaud, and Julie Maublanc, and Sylvain Dulaurent, and Jacques Descotes, and Gérard Lachâtre, and Jean-Michel Gaulier
August 1997, Nihon hoigaku zasshi = The Japanese journal of legal medicine,
Laurent Imbert, and Alexandra Boucher, and Gilles Delhome, and Thierry Cueto, and Michel Boudinaud, and Julie Maublanc, and Sylvain Dulaurent, and Jacques Descotes, and Gérard Lachâtre, and Jean-Michel Gaulier
November 2006, International journal of cardiology,
Laurent Imbert, and Alexandra Boucher, and Gilles Delhome, and Thierry Cueto, and Michel Boudinaud, and Julie Maublanc, and Sylvain Dulaurent, and Jacques Descotes, and Gérard Lachâtre, and Jean-Michel Gaulier
March 1963, Journal of occupational medicine. : official publication of the Industrial Medical Association,
Laurent Imbert, and Alexandra Boucher, and Gilles Delhome, and Thierry Cueto, and Michel Boudinaud, and Julie Maublanc, and Sylvain Dulaurent, and Jacques Descotes, and Gérard Lachâtre, and Jean-Michel Gaulier
January 2013, Przeglad lekarski,
Laurent Imbert, and Alexandra Boucher, and Gilles Delhome, and Thierry Cueto, and Michel Boudinaud, and Julie Maublanc, and Sylvain Dulaurent, and Jacques Descotes, and Gérard Lachâtre, and Jean-Michel Gaulier
May 1967, Nihon hoigaku zasshi = The Japanese journal of legal medicine,
Laurent Imbert, and Alexandra Boucher, and Gilles Delhome, and Thierry Cueto, and Michel Boudinaud, and Julie Maublanc, and Sylvain Dulaurent, and Jacques Descotes, and Gérard Lachâtre, and Jean-Michel Gaulier
December 1976, International archives of occupational and environmental health,
Laurent Imbert, and Alexandra Boucher, and Gilles Delhome, and Thierry Cueto, and Michel Boudinaud, and Julie Maublanc, and Sylvain Dulaurent, and Jacques Descotes, and Gérard Lachâtre, and Jean-Michel Gaulier
August 2019, Zhonghua lao dong wei sheng zhi ye bing za zhi = Zhonghua laodong weisheng zhiyebing zazhi = Chinese journal of industrial hygiene and occupational diseases,
Laurent Imbert, and Alexandra Boucher, and Gilles Delhome, and Thierry Cueto, and Michel Boudinaud, and Julie Maublanc, and Sylvain Dulaurent, and Jacques Descotes, and Gérard Lachâtre, and Jean-Michel Gaulier
March 2023, International journal of environmental research and public health,
Copied contents to your clipboard!