BIOMAT Database Logo BIOMAT Database Logo

Porous silicon-cyclodextrin based polymer composites for drug delivery applications. 2014

J Hernandez-Montelongo, and N Naveas, and S Degoutin, and N Tabary, and F Chai, and V Spampinato, and G Ceccone, and F Rossi, and V Torres-Costa, and M Manso-Silvan, and B Martel
Departamento de Física Aplicada, Universidad Autónoma de Madrid, 28049, Madrid, Spain. Electronic address: jacobo.hernandez@uam.es.

One of the main applications of porous silicon (PSi) in biomedicine is drug release, either as a single material or as a part of a composite. PSi composites are attractive candidates for drug delivery systems because they can display new chemical and physical characteristics, which are not exhibited by the individual constituents alone. Since cyclodextrin-based polymers have been proven efficient materials for drug delivery, in this work β-cyclodextrin-citric acid in-situ polymerization was used to functionalize two kinds of PSi (nanoporous and macroporous). The synthesized composites were characterized by microscopy techniques (SEM and AFM), physicochemical methods (ATR-FTIR, XPS, water contact angle, TGA and TBO titration) and a preliminary biological assay was performed. Both systems were tested as drug delivery platforms with two different model drugs, namely, ciprofloxacin (an antibiotic) and prednisolone (an anti-inflammatory), in two different media: pure water and PBS solution. Results show that both kinds of PSi/β-cyclodextrin-citric acid polymer composites, nano- and macro-, provide enhanced release control for drug delivery applications than non-functionalized PSi samples.

UI MeSH Term Description Entries
D011239 Prednisolone A glucocorticoid with the general properties of the corticosteroids. It is the drug of choice for all conditions in which routine systemic corticosteroid therapy is indicated, except adrenal deficiency states. Di-Adreson-F,Predate,Predonine,Di Adreson F,DiAdresonF
D002939 Ciprofloxacin A broad-spectrum antimicrobial carboxyfluoroquinoline. Bay-09867,Ciprinol,Cipro,Ciprofloxacin Hydrochloride,Ciprofloxacin Hydrochloride Anhydrous,Ciprofloxacin Monohydrochloride Monohydrate,Anhydrous, Ciprofloxacin Hydrochloride,Bay 09867,Bay09867,Hydrochloride Anhydrous, Ciprofloxacin,Hydrochloride, Ciprofloxacin,Monohydrate, Ciprofloxacin Monohydrochloride,Monohydrochloride Monohydrate, Ciprofloxacin
D004337 Drug Carriers Forms to which substances are incorporated to improve the delivery and the effectiveness of drugs. Drug carriers are used in drug-delivery systems such as the controlled-release technology to prolong in vivo drug actions, decrease drug metabolism, and reduce drug toxicity. Carriers are also used in designs to increase the effectiveness of drug delivery to the target sites of pharmacological actions. Liposomes, albumin microspheres, soluble synthetic polymers, DNA complexes, protein-drug conjugates, and carrier erythrocytes among others have been employed as biodegradable drug carriers. Drug Carrier
D000893 Anti-Inflammatory Agents Substances that reduce or suppress INFLAMMATION. Anti-Inflammatory Agent,Antiinflammatory Agent,Agents, Anti-Inflammatory,Agents, Antiinflammatory,Anti-Inflammatories,Antiinflammatories,Antiinflammatory Agents,Agent, Anti-Inflammatory,Agent, Antiinflammatory,Agents, Anti Inflammatory,Anti Inflammatories,Anti Inflammatory Agent,Anti Inflammatory Agents
D000900 Anti-Bacterial Agents Substances that inhibit the growth or reproduction of BACTERIA. Anti-Bacterial Agent,Anti-Bacterial Compound,Anti-Mycobacterial Agent,Antibacterial Agent,Antibiotics,Antimycobacterial Agent,Bacteriocidal Agent,Bacteriocide,Anti-Bacterial Compounds,Anti-Mycobacterial Agents,Antibacterial Agents,Antibiotic,Antimycobacterial Agents,Bacteriocidal Agents,Bacteriocides,Agent, Anti-Bacterial,Agent, Anti-Mycobacterial,Agent, Antibacterial,Agent, Antimycobacterial,Agent, Bacteriocidal,Agents, Anti-Bacterial,Agents, Anti-Mycobacterial,Agents, Antibacterial,Agents, Antimycobacterial,Agents, Bacteriocidal,Anti Bacterial Agent,Anti Bacterial Agents,Anti Bacterial Compound,Anti Bacterial Compounds,Anti Mycobacterial Agent,Anti Mycobacterial Agents,Compound, Anti-Bacterial,Compounds, Anti-Bacterial
D012825 Silicon A trace element that constitutes about 27.6% of the earth's crust in the form of SILICON DIOXIDE. It does not occur free in nature. Silicon has the atomic symbol Si, atomic number 14, and atomic weight [28.084; 28.086]. Silicon-28,Silicon 28
D016062 Porosity Condition of having pores or open spaces. This often refers to bones, bone implants, or bone cements, but can refer to the porous state of any solid substance. Porosities
D016503 Drug Delivery Systems Systems for the delivery of drugs to target sites of pharmacological actions. Technologies employed include those concerning drug preparation, route of administration, site targeting, metabolism, and toxicity. Drug Targeting,Delivery System, Drug,Delivery Systems, Drug,Drug Delivery System,Drug Targetings,System, Drug Delivery,Systems, Drug Delivery,Targeting, Drug,Targetings, Drug
D047392 beta-Cyclodextrins Cyclic GLUCANS consisting of seven (7) glucopyranose units linked by 1,4-glycosidic bonds. beta Cyclodextrins
D058105 Polymerization Chemical reaction in which monomeric components are combined to form POLYMERS (e.g., POLYMETHYLMETHACRYLATE). Polymerizations

Related Publications

J Hernandez-Montelongo, and N Naveas, and S Degoutin, and N Tabary, and F Chai, and V Spampinato, and G Ceccone, and F Rossi, and V Torres-Costa, and M Manso-Silvan, and B Martel
Polymer replicas of photonic porous silicon for sensing and drug delivery applications.
March 2003, Science (New York, N.Y.),
J Hernandez-Montelongo, and N Naveas, and S Degoutin, and N Tabary, and F Chai, and V Spampinato, and G Ceccone, and F Rossi, and V Torres-Costa, and M Manso-Silvan, and B Martel
Nanostructured porous silicon-polymer-based hybrids: from biosensing to drug delivery.
December 2011, Nanomedicine (London, England),
J Hernandez-Montelongo, and N Naveas, and S Degoutin, and N Tabary, and F Chai, and V Spampinato, and G Ceccone, and F Rossi, and V Torres-Costa, and M Manso-Silvan, and B Martel
Microfluidic assembly of monodisperse multistage pH-responsive polymer/porous silicon composites for precisely controlled multi-drug delivery.
May 2014, Small (Weinheim an der Bergstrasse, Germany),
J Hernandez-Montelongo, and N Naveas, and S Degoutin, and N Tabary, and F Chai, and V Spampinato, and G Ceccone, and F Rossi, and V Torres-Costa, and M Manso-Silvan, and B Martel
Optically monitored drug delivery patch based on porous silicon and polymer microneedles.
May 2016, Biomedical optics express,
J Hernandez-Montelongo, and N Naveas, and S Degoutin, and N Tabary, and F Chai, and V Spampinato, and G Ceccone, and F Rossi, and V Torres-Costa, and M Manso-Silvan, and B Martel
Tailoring Porous Silicon for Biomedical Applications: From Drug Delivery to Cancer Immunotherapy.
June 2018, Advanced materials (Deerfield Beach, Fla.),
J Hernandez-Montelongo, and N Naveas, and S Degoutin, and N Tabary, and F Chai, and V Spampinato, and G Ceccone, and F Rossi, and V Torres-Costa, and M Manso-Silvan, and B Martel
Spatially Controlled Surface Modification of Porous Silicon for Sustained Drug Delivery Applications.
February 2019, Scientific reports,
J Hernandez-Montelongo, and N Naveas, and S Degoutin, and N Tabary, and F Chai, and V Spampinato, and G Ceccone, and F Rossi, and V Torres-Costa, and M Manso-Silvan, and B Martel
Porous silicon nanomaterials: recent advances in surface engineering for controlled drug-delivery applications.
December 2019, Nanomedicine (London, England),
J Hernandez-Montelongo, and N Naveas, and S Degoutin, and N Tabary, and F Chai, and V Spampinato, and G Ceccone, and F Rossi, and V Torres-Costa, and M Manso-Silvan, and B Martel
Surface chemistry of porous silicon and implications for drug encapsulation and delivery applications.
July 2012, Advances in colloid and interface science,
J Hernandez-Montelongo, and N Naveas, and S Degoutin, and N Tabary, and F Chai, and V Spampinato, and G Ceccone, and F Rossi, and V Torres-Costa, and M Manso-Silvan, and B Martel
Controlled drug delivery from composites of nanostructured porous silicon and poly(L-lactide).
July 2012, Nanomedicine (London, England),
J Hernandez-Montelongo, and N Naveas, and S Degoutin, and N Tabary, and F Chai, and V Spampinato, and G Ceccone, and F Rossi, and V Torres-Costa, and M Manso-Silvan, and B Martel
Silicon-polymer hybrid materials for drug delivery.
September 2009, Future medicinal chemistry,
Copied contents to your clipboard!