SeaBase: a multispecies transcriptomic resource and platform for gene network inference. 2014

Antje H L Fischer, and Dmitry Mozzherin, and A Murat Eren, and Kristen D Lans, and Nathan Wilson, and Carlo Cosentino, and Joel Smith
*Marine Biological Laboratory, Woods Hole, MA 02543, USA; Department of Molecular and Cellular Biology, Harvard University, Cambridge, MA 02138, USA; Systems & Control Engineering, University of Magna Graecia, 88100 Catanzaro, Italy*Marine Biological Laboratory, Woods Hole, MA 02543, USA; Department of Molecular and Cellular Biology, Harvard University, Cambridge, MA 02138, USA; Systems & Control Engineering, University of Magna Graecia, 88100 Catanzaro, Italy jcsmith@mbl.edu.

Marine and aquatic animals are extraordinarily useful as models for identifying mechanisms of development and evolution, regeneration, resistance to cancer, longevity and symbiosis, among many other areas of research. This is due to the great diversity of these organisms and their wide-ranging capabilities. Genomics tools are essential for taking advantage of these "free lessons" of nature. However, genomics and transcriptomics are challenging in emerging model systems. Here, we present SeaBase, a tool for helping to meet these needs. Specifically, SeaBase provides a platform for sharing and searching transcriptome data. More importantly, SeaBase will support a growing number of tools for inferring gene network mechanisms. The first dataset available on SeaBase is a developmental transcriptomic profile of the sea anemone Nematostella vectensis (Anthozoa, Cnidaria). Additional datasets are currently being prepared and we are aiming to expand SeaBase to include user-supplied data for any number of marine and aquatic organisms, thereby supporting many potentially new models for gene network studies. SeaBase can be accessed online at: http://seabase.core.cli.mbl.edu.

UI MeSH Term Description Entries
D006801 Humans Members of the species Homo sapiens. Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D000818 Animals Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA. Animal,Metazoa,Animalia
D012615 Sea Anemones The order Actiniaria, in the class ANTHOZOA, comprised of large, solitary polyps. All species are carnivorous. Actiniaria,Actiniarias,Anemone, Sea,Anemones, Sea,Sea Anemone
D053263 Gene Regulatory Networks Interacting DNA-encoded regulatory subsystems in the GENOME that coordinate input from activator and repressor TRANSCRIPTION FACTORS during development, cell differentiation, or in response to environmental cues. The networks function to ultimately specify expression of particular sets of GENES for specific conditions, times, or locations. Gene Circuits,Gene Modules,Gene Networks,Transcriptional Networks,Gene Module,Circuit, Gene,Circuits, Gene,Gene Circuit,Gene Network,Gene Regulatory Network,Module, Gene,Modules, Gene,Network, Gene,Network, Gene Regulatory,Network, Transcriptional,Networks, Gene,Networks, Gene Regulatory,Networks, Transcriptional,Regulatory Network, Gene,Regulatory Networks, Gene,Transcriptional Network
D059001 Aquatic Organisms Organisms that live in water. Marine Organisms,Aquatic Organism,Marine Organism,Organism, Aquatic,Organism, Marine,Organisms, Aquatic,Organisms, Marine
D059467 Transcriptome The pattern of GENE EXPRESSION at the level of genetic transcription in a specific organism or under specific circumstances in specific cells. Transcriptomes,Gene Expression Profiles,Gene Expression Signatures,Transcriptome Profiles,Expression Profile, Gene,Expression Profiles, Gene,Expression Signature, Gene,Expression Signatures, Gene,Gene Expression Profile,Gene Expression Signature,Profile, Gene Expression,Profile, Transcriptome,Profiles, Gene Expression,Profiles, Transcriptome,Signature, Gene Expression,Signatures, Gene Expression,Transcriptome Profile
D019992 Databases as Topic Works on organized collections of records, standardized in format and content, that are stored in any of a variety of computer-readable modes. Data Banks as Topic,Data Bases as Topic,Databanks as Topic
D023281 Genomics The systematic study of the complete DNA sequences (GENOME) of organisms. Included is construction of complete genetic, physical, and transcript maps, and the analysis of this structural genomic information on a global scale such as in GENOME WIDE ASSOCIATION STUDIES. Functional Genomics,Structural Genomics,Comparative Genomics,Genomics, Comparative,Genomics, Functional,Genomics, Structural

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