Biomaterial Database

Determination of sulphacetamide, sulphadimidine or sulphathiourea in the presence of their degradation products using first derivative spectrophotometry. 1989

H E Abdellatef, and M N Elbalkiny, and A Aboulkheir

Pharmaceutical Chemistry Department, Faculty of Pharmacy, University of Zagazig, Egypt.

A method is presented for the determination of sulphacetamide sodium, sulphadimidine and sulphathiourea in the presence of their acid-induced degradation products using first derivative spectrophotometry. By measuring the absolute value of the first derivative curves at the zero contribution of the corresponding degradation products, the concentration of the intact drug can be calculated directly without interference of the degradation product. The validity of the method was confirmed using synthetic mixtures of the intact drugs with their degradation products.

UI	MeSH Term	Description	Entries
D004355	Drug Stability	The chemical and physical integrity of a pharmaceutical product.	Drug Shelf Life,Drugs Shelf Lives,Shelf Life, Drugs,Drug Stabilities,Drugs Shelf Life,Drugs Shelf Live,Life, Drugs Shelf,Shelf Life, Drug,Shelf Live, Drugs,Shelf Lives, Drugs
D006851	Hydrochloric Acid	A strong corrosive acid that is commonly used as a laboratory reagent. It is formed by dissolving hydrogen chloride in water. GASTRIC ACID is the hydrochloric acid component of GASTRIC JUICE.	Hydrogen Chloride,Muriatic Acid,Acid, Hydrochloric,Acid, Muriatic,Chloride, Hydrogen
D013056	Spectrophotometry, Ultraviolet	Determination of the spectra of ultraviolet absorption by specific molecules in gases or liquids, for example Cl2, SO2, NO2, CS2, ozone, mercury vapor, and various unsaturated compounds. (McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed)	Ultraviolet Spectrophotometry
D013409	Sulfacetamide	An anti-bacterial agent that is used topically to treat skin infections and orally for urinary tract infections.	AK-Sulf,Acetopt,Acetylsulfanilamide,Albucid,Antébor,Belph-10,Bleph,Ceta Sulfa,Cetamide,Colircusi Sulfacetamida,Coliriocilina Sulfacetam,Isopto Cetamide,Sodium Sulamyd,Sulf-10,Sulfacetamide Monosodium Salt,Sulfacetamide Sodium,Sulfacetamide, Monosodium Salt, Anhydrous,Sulfacil,Sulfacyl,Sulfair,Sulphacetamide,AK Sulf,Belph 10,Sulamyd, Sodium,Sulf 10,Sulfacetam, Coliriocilina,Sulfacetamida, Colircusi
D013418	Sulfamethazine	A sulfanilamide anti-infective agent. It has a spectrum of antimicrobial action similar to other sulfonamides.	Benzenesulfonamide, 4-amino-N-(4,6-dimethyl-2-pyrimidinyl)-,Sulfadimidine,Sulphamethazine,Sulfadimezine,Sulphamezathine
D013424	Sulfanilamides	Compounds based on 4-aminobenzenesulfonamide. The '-anil-' part of the name refers to aniline.	Sulphanilamides
D013607	Tablets	Solid dosage forms, of varying weight, size, and shape, which may be molded or compressed, and which contain a medicinal substance in pure or diluted form. (Dorland, 28th ed)	Tablet