Sensory-motor performance after acute glutathione depletion by L-buthionine sulfoximine injection into substantia nigra pars compacta. 2014

Mei-Li Díaz-Hung, and Lisette Blanco, and Nancy Pavón, and Rilda León, and Bárbara Estupiñan, and Eduardo Orta, and Klaudia Martínez, and Isabel Fernández
International Center for Neurological Restoration, Havana, Cuba. Electronic address: mldiaz@neuro.ciren.cu.

Glutathione is the major antioxidant in the living cells. Its deficit has been linked to neurodegenerative disorders as Parkinson's disease but its role in the etiology of nigral degeneration and sensory-motor performance has been poorly explored. To evaluate the effect of glutathione depletion on nigro-striatal oxidative metabolism and sensory-motor performance in rats, l-buthionine sulfoximine (15 mM) or saline solution was injected into substantia nigra pars compacta (SNpc). Then, oxidative metabolism was studied 24h and 7 days later in SNpc and corpus striatum (CS). Tyrosine hydroxylase and GFAP immunohistochemistry assays were carried out at 7 days. In addition, animals were evaluated in open field, adhesive removal, staircase and traverse beam tests. Glutathione depletion induced compensatory response in catalase activity and glial response in the in SNpc and no oxidative damage was observed. However, a loss in dopaminergic cells was found. At the same time, animals with glutathione depletion have shown poor performance in behavioral tests except for staircase test. These results suggest that glutathione depletion can be related to sensory-motor dysfunction.

UI MeSH Term Description Entries
D008124 Locomotion Movement or the ability to move from one place or another. It can refer to humans, vertebrate or invertebrate animals, and microorganisms. Locomotor Activity,Activities, Locomotor,Activity, Locomotor,Locomotor Activities
D008297 Male Males
D008845 Microinjections The injection of very small amounts of fluid, often with the aid of a microscope and microsyringes. Microinjection
D009043 Motor Activity Body movements of a human or an animal as a behavioral phenomenon. Activities, Motor,Activity, Motor,Motor Activities
D011597 Psychomotor Performance The coordination of a sensory or ideational (cognitive) process and a motor activity. Perceptual Motor Performance,Sensory Motor Performance,Visual Motor Coordination,Coordination, Visual Motor,Coordinations, Visual Motor,Motor Coordination, Visual,Motor Coordinations, Visual,Motor Performance, Perceptual,Motor Performance, Sensory,Motor Performances, Perceptual,Motor Performances, Sensory,Perceptual Motor Performances,Performance, Perceptual Motor,Performance, Psychomotor,Performance, Sensory Motor,Performances, Perceptual Motor,Performances, Psychomotor,Performances, Sensory Motor,Psychomotor Performances,Sensory Motor Performances,Visual Motor Coordinations
D003342 Corpus Striatum Striped GRAY MATTER and WHITE MATTER consisting of the NEOSTRIATUM and paleostriatum (GLOBUS PALLIDUS). It is located in front of and lateral to the THALAMUS in each cerebral hemisphere. The gray substance is made up of the CAUDATE NUCLEUS and the lentiform nucleus (the latter consisting of the GLOBUS PALLIDUS and PUTAMEN). The WHITE MATTER is the INTERNAL CAPSULE. Lenticular Nucleus,Lentiform Nucleus,Lentiform Nuclei,Nucleus Lentiformis,Lentiformis, Nucleus,Nuclei, Lentiform,Nucleus, Lenticular,Nucleus, Lentiform,Striatum, Corpus
D005904 Glial Fibrillary Acidic Protein An intermediate filament protein found only in glial cells or cells of glial origin. MW 51,000. Glial Intermediate Filament Protein,Astroprotein,GFA-Protein,Glial Fibrillary Acid Protein,GFA Protein
D005978 Glutathione A tripeptide with many roles in cells. It conjugates to drugs to make them more soluble for excretion, is a cofactor for some enzymes, is involved in protein disulfide bond rearrangement and reduces peroxides. Reduced Glutathione,gamma-L-Glu-L-Cys-Gly,gamma-L-Glutamyl-L-Cysteinylglycine,Glutathione, Reduced,gamma L Glu L Cys Gly,gamma L Glutamyl L Cysteinylglycine
D000818 Animals Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA. Animal,Metazoa,Animalia
D014446 Tyrosine 3-Monooxygenase An enzyme that catalyzes the conversion of L-tyrosine, tetrahydrobiopterin, and oxygen to 3,4-dihydroxy-L-phenylalanine, dihydrobiopterin, and water. EC 1.14.16.2. Tyrosine Hydroxylase,3-Monooxygenase, Tyrosine,Hydroxylase, Tyrosine,Tyrosine 3 Monooxygenase

Related Publications

Mei-Li Díaz-Hung, and Lisette Blanco, and Nancy Pavón, and Rilda León, and Bárbara Estupiñan, and Eduardo Orta, and Klaudia Martínez, and Isabel Fernández
May 1993, Cancer research,
Mei-Li Díaz-Hung, and Lisette Blanco, and Nancy Pavón, and Rilda León, and Bárbara Estupiñan, and Eduardo Orta, and Klaudia Martínez, and Isabel Fernández
January 1990, Life sciences,
Mei-Li Díaz-Hung, and Lisette Blanco, and Nancy Pavón, and Rilda León, and Bárbara Estupiñan, and Eduardo Orta, and Klaudia Martínez, and Isabel Fernández
May 1988, Journal of neurochemistry,
Mei-Li Díaz-Hung, and Lisette Blanco, and Nancy Pavón, and Rilda León, and Bárbara Estupiñan, and Eduardo Orta, and Klaudia Martínez, and Isabel Fernández
December 1979, Experimental neurology,
Mei-Li Díaz-Hung, and Lisette Blanco, and Nancy Pavón, and Rilda León, and Bárbara Estupiñan, and Eduardo Orta, and Klaudia Martínez, and Isabel Fernández
January 2018, Journal of immunology research,
Mei-Li Díaz-Hung, and Lisette Blanco, and Nancy Pavón, and Rilda León, and Bárbara Estupiñan, and Eduardo Orta, and Klaudia Martínez, and Isabel Fernández
June 1986, Neuroscience letters,
Mei-Li Díaz-Hung, and Lisette Blanco, and Nancy Pavón, and Rilda León, and Bárbara Estupiñan, and Eduardo Orta, and Klaudia Martínez, and Isabel Fernández
November 2006, The Journal of neuroscience : the official journal of the Society for Neuroscience,
Mei-Li Díaz-Hung, and Lisette Blanco, and Nancy Pavón, and Rilda León, and Bárbara Estupiñan, and Eduardo Orta, and Klaudia Martínez, and Isabel Fernández
December 1979, Naunyn-Schmiedeberg's archives of pharmacology,
Mei-Li Díaz-Hung, and Lisette Blanco, and Nancy Pavón, and Rilda León, and Bárbara Estupiñan, and Eduardo Orta, and Klaudia Martínez, and Isabel Fernández
July 1973, Science (New York, N.Y.),
Mei-Li Díaz-Hung, and Lisette Blanco, and Nancy Pavón, and Rilda León, and Bárbara Estupiñan, and Eduardo Orta, and Klaudia Martínez, and Isabel Fernández
January 2009, Journal of neural transmission. Supplementum,
Copied contents to your clipboard!