Biomaterial Database

Indoleamine 2,3-dioxygenase--a new antioxidant enzyme. 1989

Y Sun

Radiation Research Laboratory, University of Iowa.

Indoleamine 2,3-dioxygenase (IDO) was first found in rabbit intestine by Hayaishi et al. in 1963. The enzyme has a broad substrate specificity for various indoleamine derivatives and utilizes the superoxide anion as an oxygen source. IDO catalyzes the oxidative cleavage of the indole ring of several important regulatory molecules including tryptophan, tryptamine, serotonin and melatonin, and produces a new type of biogenic amine that may be termed an anthraniloylalkylamine, as shown in Fig. 1.

UI	MeSH Term	Description	Entries
D006801	Humans	Members of the species Homo sapiens.	Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D000818	Animals	Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA.	Animal,Metazoa,Animalia
D000975	Antioxidants	Naturally occurring or synthetic substances that inhibit or retard oxidation reactions. They counteract the damaging effects of oxidation in animal tissues.	Anti-Oxidant,Antioxidant,Antioxidant Activity,Endogenous Antioxidant,Endogenous Antioxidants,Anti-Oxidant Effect,Anti-Oxidant Effects,Anti-Oxidants,Antioxidant Effect,Antioxidant Effects,Activity, Antioxidant,Anti Oxidant,Anti Oxidant Effect,Anti Oxidant Effects,Anti Oxidants,Antioxidant, Endogenous,Antioxidants, Endogenous
D014366	Tryptophan Oxygenase	A dioxygenase with specificity for the oxidation of the indoleamine ring of TRYPTOPHAN. It is a LIVER-specific enzyme that is the first and rate limiting enzyme in the kynurenine pathway of TRYPTOPHAN catabolism.	Tryptophan Pyrrolase,TDO Dioxygenase,Tryptophan 2,3-Dioxygenase,2,3-Dioxygenase, Tryptophan,Dioxygenase, TDO,Oxygenase, Tryptophan,Pyrrolase, Tryptophan,Tryptophan 2,3 Dioxygenase
D050503	Indoleamine-Pyrrole 2,3,-Dioxygenase	A dioxygenase with specificity for the oxidation of the indoleamine ring of TRYPTOPHAN. It is an extrahepatic enzyme that plays a role in metabolism as the first and rate limiting enzyme in the kynurenine pathway of TRYPTOPHAN catabolism.	IDO Dioxygenase,Indolamine-2,3-Dioxygenase,Indoleamine 2,3-Dioxygenase,Indoleamine-Oxygen 2,3-Oxidoreductase (Decyclizing),Dioxygenase, IDO,Indolamine 2,3 Dioxygenase,Indoleamine 2,3 Dioxygenase

Related Publications

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