Sustained delivery of cytarabine-loaded vesicular phospholipid gels for treatment of xenografted glioma. 2014

Na Qi, and Cuifang Cai, and Wei Zhang, and Yantao Niu, and Jingyu Yang, and Lihui Wang, and Bin Tian, and Xiaona Liu, and Xia Lin, and Yu Zhang, and Yan Zhang, and Haibing He, and Kang Chen, and Xing Tang
Department of Pharmaceutics, Shenyang Pharmaceutical University, Shenyang 110016, PR China; Department of Pharmaceutics, Guilin Medical University, Guilin 541004, PR China.

This study described the development of vesicular phospholipid gels (VPGs) for sustained delivery of cytarabine (Ara-C) for the treatment of xenografted glioma. Ara-C-loaded VPGs in the state of a semisolid phospholipid dispersion looked like numerous vesicles tightly packing together under the freeze-fracture electron microscopy (FF-TEM), their release profiles displayed sustained drug release up to 384 h in vitro. The biodistribution of Ara-C in the rat brain showed that Ara-C-loaded VPGs could maintain therapeutic concentrations up to 5mm distance from the implantation site in brain tissue within 28 days. At the same time, fluorescence micrograph confirmed drug distribution in brain tissue visually. Furthermore, after single administration, Ara-C-loaded VPGs group significantly inhibited the U87-MG glioma growth in right flank in comparison with Ara-C solution (p<0.01). It was explained that the entrapped drug in VPGs could avoid degradation from cytidine deaminase and sustained release of drug from Ara-C-loaded VPGs could maintain the effective therapeutic levels for a long time around the tumor. In conclusion, Ara-C-loaded VPGs, with the properties of sustained release, high penetration capacity, nontoxicity and no shape restriction of the surgical cavity, are promising local delivery systems for post-surgical sustained chemotherapy against glioma.

UI MeSH Term Description Entries
D008819 Mice, Nude Mutant mice homozygous for the recessive gene "nude" which fail to develop a thymus. They are useful in tumor studies and studies on immune responses. Athymic Mice,Mice, Athymic,Nude Mice,Mouse, Athymic,Mouse, Nude,Athymic Mouse,Nude Mouse
D010743 Phospholipids Lipids containing one or more phosphate groups, particularly those derived from either glycerol (phosphoglycerides see GLYCEROPHOSPHOLIPIDS) or sphingosine (SPHINGOLIPIDS). They are polar lipids that are of great importance for the structure and function of cell membranes and are the most abundant of membrane lipids, although not stored in large amounts in the system. Phosphatides,Phospholipid
D001932 Brain Neoplasms Neoplasms of the intracranial components of the central nervous system, including the cerebral hemispheres, basal ganglia, hypothalamus, thalamus, brain stem, and cerebellum. Brain neoplasms are subdivided into primary (originating from brain tissue) and secondary (i.e., metastatic) forms. Primary neoplasms are subdivided into benign and malignant forms. In general, brain tumors may also be classified by age of onset, histologic type, or presenting location in the brain. Brain Cancer,Brain Metastases,Brain Tumors,Cancer of Brain,Malignant Primary Brain Tumors,Neoplasms, Intracranial,Benign Neoplasms, Brain,Brain Neoplasm, Primary,Brain Neoplasms, Benign,Brain Neoplasms, Malignant,Brain Neoplasms, Malignant, Primary,Brain Neoplasms, Primary Malignant,Brain Tumor, Primary,Brain Tumor, Recurrent,Cancer of the Brain,Intracranial Neoplasms,Malignant Neoplasms, Brain,Malignant Primary Brain Neoplasms,Neoplasms, Brain,Neoplasms, Brain, Benign,Neoplasms, Brain, Malignant,Neoplasms, Brain, Primary,Primary Brain Neoplasms,Primary Malignant Brain Neoplasms,Primary Malignant Brain Tumors,Benign Brain Neoplasm,Benign Brain Neoplasms,Benign Neoplasm, Brain,Brain Benign Neoplasm,Brain Benign Neoplasms,Brain Cancers,Brain Malignant Neoplasm,Brain Malignant Neoplasms,Brain Metastase,Brain Neoplasm,Brain Neoplasm, Benign,Brain Neoplasm, Malignant,Brain Neoplasms, Primary,Brain Tumor,Brain Tumors, Recurrent,Cancer, Brain,Intracranial Neoplasm,Malignant Brain Neoplasm,Malignant Brain Neoplasms,Malignant Neoplasm, Brain,Neoplasm, Brain,Neoplasm, Intracranial,Primary Brain Neoplasm,Primary Brain Tumor,Primary Brain Tumors,Recurrent Brain Tumor,Recurrent Brain Tumors,Tumor, Brain
D003561 Cytarabine A pyrimidine nucleoside analog that is used mainly in the treatment of leukemia, especially acute non-lymphoblastic leukemia. Cytarabine is an antimetabolite antineoplastic agent that inhibits the synthesis of DNA. Its actions are specific for the S phase of the cell cycle. It also has antiviral and immunosuppressant properties. (From Martindale, The Extra Pharmacopoeia, 30th ed, p472) Ara-C,Arabinofuranosylcytosine,Arabinosylcytosine,Cytosine Arabinoside,Aracytidine,Aracytine,Cytarabine Hydrochloride,Cytonal,Cytosar,Cytosar-U,beta-Ara C,Ara C,Arabinoside, Cytosine,Cytosar U,beta Ara C
D003692 Delayed-Action Preparations Dosage forms of a drug that act over a period of time by controlled-release processes or technology. Controlled Release Formulation,Controlled-Release Formulation,Controlled-Release Preparation,Delayed-Action Preparation,Depot Preparation,Depot Preparations,Extended Release Formulation,Extended Release Preparation,Prolonged-Action Preparation,Prolonged-Action Preparations,Sustained Release Formulation,Sustained-Release Preparation,Sustained-Release Preparations,Timed-Release Preparation,Timed-Release Preparations,Controlled-Release Formulations,Controlled-Release Preparations,Extended Release Formulations,Extended Release Preparations,Slow Release Formulation,Sustained Release Formulations,Controlled Release Formulations,Controlled Release Preparation,Controlled Release Preparations,Delayed Action Preparation,Delayed Action Preparations,Formulation, Controlled Release,Formulations, Controlled Release,Prolonged Action Preparation,Release Formulation, Controlled,Release Formulations, Controlled,Sustained Release Preparation,Timed Release Preparation,Timed Release Preparations
D005782 Gels Colloids with a solid continuous phase and liquid as the dispersed phase; gels may be unstable when, due to temperature or other cause, the solid phase liquefies; the resulting colloid is called a sol.
D005910 Glioma Benign and malignant central nervous system neoplasms derived from glial cells (i.e., astrocytes, oligodendrocytes, and ependymocytes). Astrocytes may give rise to astrocytomas (ASTROCYTOMA) or glioblastoma multiforme (see GLIOBLASTOMA). Oligodendrocytes give rise to oligodendrogliomas (OLIGODENDROGLIOMA) and ependymocytes may undergo transformation to become EPENDYMOMA; CHOROID PLEXUS NEOPLASMS; or colloid cysts of the third ventricle. (From Escourolle et al., Manual of Basic Neuropathology, 2nd ed, p21) Glial Cell Tumors,Malignant Glioma,Mixed Glioma,Glial Cell Tumor,Glioma, Malignant,Glioma, Mixed,Gliomas,Gliomas, Malignant,Gliomas, Mixed,Malignant Gliomas,Mixed Gliomas,Tumor, Glial Cell,Tumors, Glial Cell
D000818 Animals Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA. Animal,Metazoa,Animalia
D000964 Antimetabolites, Antineoplastic Antimetabolites that are useful in cancer chemotherapy. Antineoplastic Antimetabolites
D014018 Tissue Distribution Accumulation of a drug or chemical substance in various organs (including those not relevant to its pharmacologic or therapeutic action). This distribution depends on the blood flow or perfusion rate of the organ, the ability of the drug to penetrate organ membranes, tissue specificity, protein binding. The distribution is usually expressed as tissue to plasma ratios. Distribution, Tissue,Distributions, Tissue,Tissue Distributions

Related Publications

Na Qi, and Cuifang Cai, and Wei Zhang, and Yantao Niu, and Jingyu Yang, and Lihui Wang, and Bin Tian, and Xiaona Liu, and Xia Lin, and Yu Zhang, and Yan Zhang, and Haibing He, and Kang Chen, and Xing Tang
January 2020, Drug design, development and therapy,
Na Qi, and Cuifang Cai, and Wei Zhang, and Yantao Niu, and Jingyu Yang, and Lihui Wang, and Bin Tian, and Xiaona Liu, and Xia Lin, and Yu Zhang, and Yan Zhang, and Haibing He, and Kang Chen, and Xing Tang
January 2010, Methods in molecular biology (Clifton, N.J.),
Na Qi, and Cuifang Cai, and Wei Zhang, and Yantao Niu, and Jingyu Yang, and Lihui Wang, and Bin Tian, and Xiaona Liu, and Xia Lin, and Yu Zhang, and Yan Zhang, and Haibing He, and Kang Chen, and Xing Tang
April 2001, International journal of pharmaceutics,
Na Qi, and Cuifang Cai, and Wei Zhang, and Yantao Niu, and Jingyu Yang, and Lihui Wang, and Bin Tian, and Xiaona Liu, and Xia Lin, and Yu Zhang, and Yan Zhang, and Haibing He, and Kang Chen, and Xing Tang
August 2017, International journal of pharmaceutics,
Na Qi, and Cuifang Cai, and Wei Zhang, and Yantao Niu, and Jingyu Yang, and Lihui Wang, and Bin Tian, and Xiaona Liu, and Xia Lin, and Yu Zhang, and Yan Zhang, and Haibing He, and Kang Chen, and Xing Tang
January 2007, Journal of liposome research,
Na Qi, and Cuifang Cai, and Wei Zhang, and Yantao Niu, and Jingyu Yang, and Lihui Wang, and Bin Tian, and Xiaona Liu, and Xia Lin, and Yu Zhang, and Yan Zhang, and Haibing He, and Kang Chen, and Xing Tang
October 2013, Die Pharmazie,
Na Qi, and Cuifang Cai, and Wei Zhang, and Yantao Niu, and Jingyu Yang, and Lihui Wang, and Bin Tian, and Xiaona Liu, and Xia Lin, and Yu Zhang, and Yan Zhang, and Haibing He, and Kang Chen, and Xing Tang
January 2016, Drug development and industrial pharmacy,
Na Qi, and Cuifang Cai, and Wei Zhang, and Yantao Niu, and Jingyu Yang, and Lihui Wang, and Bin Tian, and Xiaona Liu, and Xia Lin, and Yu Zhang, and Yan Zhang, and Haibing He, and Kang Chen, and Xing Tang
April 2003, International journal of pharmaceutics,
Na Qi, and Cuifang Cai, and Wei Zhang, and Yantao Niu, and Jingyu Yang, and Lihui Wang, and Bin Tian, and Xiaona Liu, and Xia Lin, and Yu Zhang, and Yan Zhang, and Haibing He, and Kang Chen, and Xing Tang
September 2018, Daru : journal of Faculty of Pharmacy, Tehran University of Medical Sciences,
Na Qi, and Cuifang Cai, and Wei Zhang, and Yantao Niu, and Jingyu Yang, and Lihui Wang, and Bin Tian, and Xiaona Liu, and Xia Lin, and Yu Zhang, and Yan Zhang, and Haibing He, and Kang Chen, and Xing Tang
March 2023, Pharmaceutics,
Copied contents to your clipboard!