BIOMAT Database Logo BIOMAT Database Logo

Activation of Dopamine D1 Receptors Regulates Dendritic Morphogenesis Through Rac1 and RhoA in Prefrontal Cortex Neurons. 2015

Juan Li, and Jingjing Gu, and Bin Wang, and Minjuan Xie, and Lu Huang, and Yutong Liu, and Lei Zhang, and Jinhua Xue, and Fukun Guo, and Lin Zhang, and Lu Zhang
Key Laboratory of Functional Proteomics of Guangdong Province, Department of Pathophysiology, Southern Medical University, Guangzhou, 510515, China.

Dopamine (DA) is an important regulator of neuronal plasticity in the prefrontal cortex (PFC) and plays a critical role in addiction-related neuroadaptation. The Rho GTPases, including Rac1, RhoA and Cdc42, are key regulators of actin cytoskeleton rearrangement that play important roles in dendritic morphogenesis. The goal of the current study was to use cultures of primary PFC neurons to gain a better understanding of the molecular mechanisms underlying DA-induced dendritic morphogenesis, a phenomenon that mimics the increase in DA synaptic transmission observed in the PFC of in vivo cocaine administration. We investigated the effects of repeated DA treatments on dendritic morphology changes in PFC neurons, and identified Rac1 and RhoA as downstream effectors of D1 receptors during the regulation of dendritic morphogenesis. Importantly, we found that D1 receptor-regulated Rac1 and RhoA have distinct roles in the regulation of dendritic morphogenesis after repeated DA treatments. Our data provide the first evidence that Rac1 and RhoA are effectors of D1 receptor signaling during dendritic morphogenesis and represent new signaling molecules involved in long-lasting neuroadaptation in the PFC.

UI MeSH Term Description Entries
D009024 Morphogenesis The development of anatomical structures to create the form of a single- or multi-cell organism. Morphogenesis provides form changes of a part, parts, or the whole organism.
D009474 Neurons The basic cellular units of nervous tissue. Each neuron consists of a body, an axon, and dendrites. Their purpose is to receive, conduct, and transmit impulses in the NERVOUS SYSTEM. Nerve Cells,Cell, Nerve,Cells, Nerve,Nerve Cell,Neuron
D002478 Cells, Cultured Cells propagated in vitro in special media conducive to their growth. Cultured cells are used to study developmental, morphologic, metabolic, physiologic, and genetic processes, among others. Cultured Cells,Cell, Cultured,Cultured Cell
D003712 Dendrites Extensions of the nerve cell body. They are short and branched and receive stimuli from other NEURONS. Dendrite
D000818 Animals Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA. Animal,Metazoa,Animalia
D000831 Animals, Newborn Refers to animals in the period of time just after birth. Animals, Neonatal,Animal, Neonatal,Animal, Newborn,Neonatal Animal,Neonatal Animals,Newborn Animal,Newborn Animals
D001552 Benzazepines Compounds with BENZENE fused to AZEPINES.
D017207 Rats, Sprague-Dawley A strain of albino rat used widely for experimental purposes because of its calmness and ease of handling. It was developed by the Sprague-Dawley Animal Company. Holtzman Rat,Rats, Holtzman,Sprague-Dawley Rat,Rats, Sprague Dawley,Holtzman Rats,Rat, Holtzman,Rat, Sprague-Dawley,Sprague Dawley Rat,Sprague Dawley Rats,Sprague-Dawley Rats
D017397 Prefrontal Cortex The rostral part of the frontal lobe, bounded by the inferior precentral fissure in humans, which receives projection fibers from the MEDIODORSAL NUCLEUS OF THE THALAMUS. The prefrontal cortex receives afferent fibers from numerous structures of the DIENCEPHALON; MESENCEPHALON; and LIMBIC SYSTEM as well as cortical afferents of visual, auditory, and somatic origin. Anterior Prefrontal Cortex,Brodmann Area 10,Brodmann Area 11,Brodmann Area 12,Brodmann Area 47,Brodmann's Area 10,Brodmann's Area 11,Brodmann's Area 12,Brodmann's Area 47,Pars Orbitalis,Frontal Sulcus,Gyrus Frontalis Inferior,Gyrus Frontalis Superior,Gyrus Orbitalis,Gyrus Rectus,Inferior Frontal Gyrus,Lateral Orbitofrontal Cortex,Marginal Gyrus,Medial Frontal Gyrus,Olfactory Sulci,Orbital Area,Orbital Cortex,Orbital Gyri,Orbitofrontal Cortex,Orbitofrontal Gyri,Orbitofrontal Gyrus,Orbitofrontal Region,Rectal Gyrus,Rectus Gyrus,Straight Gyrus,Subcallosal Area,Superior Frontal Convolution,Superior Frontal Gyrus,Ventral Medial Prefrontal Cortex,Ventromedial Prefrontal Cortex,Anterior Prefrontal Cortices,Area 10, Brodmann,Area 10, Brodmann's,Area 11, Brodmann,Area 11, Brodmann's,Area 12, Brodmann,Area 12, Brodmann's,Area 47, Brodmann,Area 47, Brodmann's,Area, Orbital,Area, Subcallosal,Brodmanns Area 10,Brodmanns Area 11,Brodmanns Area 12,Brodmanns Area 47,Convolution, Superior Frontal,Convolutions, Superior Frontal,Cortex, Anterior Prefrontal,Cortex, Lateral Orbitofrontal,Cortex, Orbital,Cortex, Orbitofrontal,Cortex, Prefrontal,Cortex, Ventromedial Prefrontal,Cortices, Ventromedial Prefrontal,Frontal Convolution, Superior,Frontal Gyrus, Inferior,Frontal Gyrus, Medial,Frontal Gyrus, Superior,Frontalis Superior, Gyrus,Gyrus, Inferior Frontal,Gyrus, Marginal,Gyrus, Medial Frontal,Gyrus, Orbital,Gyrus, Orbitofrontal,Gyrus, Rectal,Gyrus, Rectus,Gyrus, Straight,Gyrus, Superior Frontal,Inferior, Gyrus Frontalis,Lateral Orbitofrontal Cortices,Olfactory Sulcus,Orbital Areas,Orbital Cortices,Orbital Gyrus,Orbitalis, Pars,Orbitofrontal Cortex, Lateral,Orbitofrontal Cortices,Orbitofrontal Cortices, Lateral,Orbitofrontal Regions,Prefrontal Cortex, Anterior,Prefrontal Cortex, Ventromedial,Prefrontal Cortices, Anterior,Region, Orbitofrontal,Subcallosal Areas,Sulcus, Frontal,Superior Frontal Convolutions,Superior, Gyrus Frontalis,Ventromedial Prefrontal Cortices
D017447 Receptors, Dopamine D1 A subfamily of G-PROTEIN-COUPLED RECEPTORS that bind the neurotransmitter DOPAMINE and modulate its effects. D1-class receptor genes lack INTRONS, and the receptors stimulate ADENYLYL CYCLASES. Dopamine D1 Receptors,Dopamine-D1 Receptor,D1 Receptors, Dopamine,Dopamine D1 Receptor,Receptor, Dopamine-D1

Related Publications

Juan Li, and Jingjing Gu, and Bin Wang, and Minjuan Xie, and Lu Huang, and Yutong Liu, and Lei Zhang, and Jinhua Xue, and Fukun Guo, and Lin Zhang, and Lu Zhang
Dopamine D1 receptor activation regulates sodium channel-dependent EPSP amplification in rat prefrontal cortex pyramidal neurons.
June 2007, The Journal of physiology,
Juan Li, and Jingjing Gu, and Bin Wang, and Minjuan Xie, and Lu Huang, and Yutong Liu, and Lei Zhang, and Jinhua Xue, and Fukun Guo, and Lin Zhang, and Lu Zhang
D1 dopamine receptors in prefrontal cortex: involvement in working memory.
February 1991, Science (New York, N.Y.),
Juan Li, and Jingjing Gu, and Bin Wang, and Minjuan Xie, and Lu Huang, and Yutong Liu, and Lei Zhang, and Jinhua Xue, and Fukun Guo, and Lin Zhang, and Lu Zhang
Neuropeptide orphanin FQ inhibits dendritic morphogenesis through activation of RhoA.
October 2013, Developmental neurobiology,
Juan Li, and Jingjing Gu, and Bin Wang, and Minjuan Xie, and Lu Huang, and Yutong Liu, and Lei Zhang, and Jinhua Xue, and Fukun Guo, and Lin Zhang, and Lu Zhang
Modulation of memory fields by dopamine D1 receptors in prefrontal cortex.
August 1995, Nature,
Juan Li, and Jingjing Gu, and Bin Wang, and Minjuan Xie, and Lu Huang, and Yutong Liu, and Lei Zhang, and Jinhua Xue, and Fukun Guo, and Lin Zhang, and Lu Zhang
Potentiation of NMDA receptor currents by dopamine D1 receptors in prefrontal cortex.
February 2004, Proceedings of the National Academy of Sciences of the United States of America,
Juan Li, and Jingjing Gu, and Bin Wang, and Minjuan Xie, and Lu Huang, and Yutong Liu, and Lei Zhang, and Jinhua Xue, and Fukun Guo, and Lin Zhang, and Lu Zhang
Interaction of dopamine D1 with NMDA NR1 receptors in rat prefrontal cortex.
April 2009, European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology,
Juan Li, and Jingjing Gu, and Bin Wang, and Minjuan Xie, and Lu Huang, and Yutong Liu, and Lei Zhang, and Jinhua Xue, and Fukun Guo, and Lin Zhang, and Lu Zhang
Cellular colocalization of dopamine D1 and D2 receptors in rat medial prefrontal cortex.
February 1995, Synapse (New York, N.Y.),
Juan Li, and Jingjing Gu, and Bin Wang, and Minjuan Xie, and Lu Huang, and Yutong Liu, and Lei Zhang, and Jinhua Xue, and Fukun Guo, and Lin Zhang, and Lu Zhang
Cellular distribution of dopamine D1 and D2 receptors in rat medial prefrontal cortex.
June 1993, The Journal of neuroscience : the official journal of the Society for Neuroscience,
Juan Li, and Jingjing Gu, and Bin Wang, and Minjuan Xie, and Lu Huang, and Yutong Liu, and Lei Zhang, and Jinhua Xue, and Fukun Guo, and Lin Zhang, and Lu Zhang
EphB receptors regulate dendritic spine morphogenesis through the recruitment/phosphorylation of focal adhesion kinase and RhoA activation.
January 2006, The Journal of biological chemistry,
Juan Li, and Jingjing Gu, and Bin Wang, and Minjuan Xie, and Lu Huang, and Yutong Liu, and Lei Zhang, and Jinhua Xue, and Fukun Guo, and Lin Zhang, and Lu Zhang
Appetitive instrumental learning requires coincident activation of NMDA and dopamine D1 receptors within the medial prefrontal cortex.
February 2002, The Journal of neuroscience : the official journal of the Society for Neuroscience,
Copied contents to your clipboard!