Tissucol (human fibrin seal) has an adhesive as well as a haemostatic effect on tissues. It has been used in larynx surgery favouring adhesion between cartilages, mucosae and muscles. The use of Tissucol has particularly been successful in: 1) bilateral cordectomy as, besides avoiding the temporary application of a silactic sheet to matain an open glottic chink, it also prevented webbing. 2) Authors also underline the advantages of applying Tissucol by the "duploject" device for closure of pharyngeal fistulae and by the "Spray-set" device for large pharyngo-oesophageal surfaces and neck fascia.