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Twenty-two patients with inoperable adenocarcinoma of the pancreas were treated with 5-fluorouracil (5-FU), mitomycin C (Mito-C), and 1(-2-chloroethyl)-3-(4-methylcyclohexyl)-1-nitrosourea (MeCCNU). Fifteen were evaluable by completing 2 months of therapy. Two patients achieved a complete remission with the above combination. A partial remission seen in four other patients, which produced a response rate of 40% of evaluable, and 27% of entered, patients. Three had stable disease. The average time to progression in this study was 8 months. This combination was well tolerated and no deaths were secondary to drug therapy. Mucositis, leukopenia, thrombocytopenia, and hyperpigmentation were the significant toxicities seen in this study. These observations are worthy of further investigation.
C Vaughn, and
J Chapman, and
B Chinn, and
D Ward, and
G Groshko, and
B Maniscalco, and
S Reznik, and
D Piper
January 1980,
Cancer chemotherapy and pharmacology,
C Vaughn, and
J Chapman, and
B Chinn, and
D Ward, and
G Groshko, and
B Maniscalco, and
S Reznik, and
D Piper
September 1978,
Cancer treatment reports,
C Vaughn, and
J Chapman, and
B Chinn, and
D Ward, and
G Groshko, and
B Maniscalco, and
S Reznik, and
D Piper
September 1978,
Cancer treatment reports,
C Vaughn, and
J Chapman, and
B Chinn, and
D Ward, and
G Groshko, and
B Maniscalco, and
S Reznik, and
D Piper
September 1977,
Clinical oncology,
C Vaughn, and
J Chapman, and
B Chinn, and
D Ward, and
G Groshko, and
B Maniscalco, and
S Reznik, and
D Piper
October 1986,
American journal of clinical oncology,
C Vaughn, and
J Chapman, and
B Chinn, and
D Ward, and
G Groshko, and
B Maniscalco, and
S Reznik, and
D Piper
November 1980,
Cancer,
C Vaughn, and
J Chapman, and
B Chinn, and
D Ward, and
G Groshko, and
B Maniscalco, and
S Reznik, and
D Piper
January 1980,
Cancer clinical trials,
C Vaughn, and
J Chapman, and
B Chinn, and
D Ward, and
G Groshko, and
B Maniscalco, and
S Reznik, and
D Piper
October 1984,
American journal of clinical oncology,
C Vaughn, and
J Chapman, and
B Chinn, and
D Ward, and
G Groshko, and
B Maniscalco, and
S Reznik, and
D Piper
November 1977,
Cancer treatment reports,
C Vaughn, and
J Chapman, and
B Chinn, and
D Ward, and
G Groshko, and
B Maniscalco, and
S Reznik, and
D Piper
March 1977,
Clinical oncology,
