Meta-analysis of face processing event-related potentials in schizophrenia. 2015

Amanda McCleery, and Junghee Lee, and Aditi Joshi, and Jonathan K Wynn, and Gerhard S Hellemann, and Michael F Green
UCLA Semel Institute for Neuroscience and Human Behavior, David Geffen School of Medicine, University of California, Los Angeles, California. Electronic address: amccleery@mednet.ucla.edu.

BACKGROUND Schizophrenia is associated with impaired face processing. N170 and N250 are two event-related potentials that have been studied in relation to face processing in schizophrenia, but the results have been mixed. The aim of this article was to conduct a meta-analysis of N170 and N250 in schizophrenia to evaluate trends and resolve the inconsistencies. METHODS Twenty-one studies of N170 (n = 438 schizophrenia patients, n = 418 control subjects) and six studies of N250 (n = 149 schizophrenia patients, n = 151 control subjects) were evaluated. Hedges' g was calculated for each study, and the overall weighted mean effect size (ES) was calculated for N170 and N250. Homogeneity of the ES distributions, potential publication bias, and impact of potential moderators were also assessed. RESULTS The amplitude of both N170 and N250 to face stimuli was smaller in patients than control subjects (N170 ES = .64; N250 ES = .49; ps < .001). The distributions of the ES were homogeneous (ps > .90), and there was no indication of a publication bias. We found no significant effect of task requirements regarding judgments of the face stimuli. Moreover, we found no significant difference between the ES for N170 and N250. CONCLUSIONS Though findings of individual studies have been mixed, the results of the meta-analysis strongly support disruption of N170 and N250 in schizophrenia. The comparable effect sizes across the two waveforms suggest that the well-established behavioral deficit in face emotion processing is mirrored in an underlying neural impairment for processing faces.

UI MeSH Term Description Entries
D008279 Magnetic Resonance Imaging Non-invasive method of demonstrating internal anatomy based on the principle that atomic nuclei in a strong magnetic field absorb pulses of radiofrequency energy and emit them as radiowaves which can be reconstructed into computerized images. The concept includes proton spin tomographic techniques. Chemical Shift Imaging,MR Tomography,MRI Scans,MRI, Functional,Magnetic Resonance Image,Magnetic Resonance Imaging, Functional,Magnetization Transfer Contrast Imaging,NMR Imaging,NMR Tomography,Tomography, NMR,Tomography, Proton Spin,fMRI,Functional Magnetic Resonance Imaging,Imaging, Chemical Shift,Proton Spin Tomography,Spin Echo Imaging,Steady-State Free Precession MRI,Tomography, MR,Zeugmatography,Chemical Shift Imagings,Echo Imaging, Spin,Echo Imagings, Spin,Functional MRI,Functional MRIs,Image, Magnetic Resonance,Imaging, Magnetic Resonance,Imaging, NMR,Imaging, Spin Echo,Imagings, Chemical Shift,Imagings, Spin Echo,MRI Scan,MRIs, Functional,Magnetic Resonance Images,Resonance Image, Magnetic,Scan, MRI,Scans, MRI,Shift Imaging, Chemical,Shift Imagings, Chemical,Spin Echo Imagings,Steady State Free Precession MRI
D010364 Pattern Recognition, Visual Mental process to visually perceive a critical number of facts (the pattern), such as characters, shapes, displays, or designs. Recognition, Visual Pattern,Visual Pattern Recognition
D001921 Brain The part of CENTRAL NERVOUS SYSTEM that is contained within the skull (CRANIUM). Arising from the NEURAL TUBE, the embryonic brain is comprised of three major parts including PROSENCEPHALON (the forebrain); MESENCEPHALON (the midbrain); and RHOMBENCEPHALON (the hindbrain). The developed brain consists of CEREBRUM; CEREBELLUM; and other structures in the BRAIN STEM. Encephalon
D004569 Electroencephalography Recording of electric currents developed in the brain by means of electrodes applied to the scalp, to the surface of the brain, or placed within the substance of the brain. EEG,Electroencephalogram,Electroencephalograms
D004644 Emotions Those affective states which can be experienced and have arousing and motivational properties. Feelings,Regret,Emotion,Feeling,Regrets
D005071 Evoked Potentials Electrical responses recorded from nerve, muscle, SENSORY RECEPTOR, or area of the CENTRAL NERVOUS SYSTEM following stimulation. They range from less than a microvolt to several microvolts. The evoked potential can be auditory (EVOKED POTENTIALS, AUDITORY), somatosensory (EVOKED POTENTIALS, SOMATOSENSORY), visual (EVOKED POTENTIALS, VISUAL), or motor (EVOKED POTENTIALS, MOTOR), or other modalities that have been reported. Event Related Potential,Event-Related Potentials,Evoked Potential,N100 Evoked Potential,P50 Evoked Potential,N1 Wave,N100 Evoked Potentials,N2 Wave,N200 Evoked Potentials,N3 Wave,N300 Evoked Potentials,N4 Wave,N400 Evoked Potentials,P2 Wave,P200 Evoked Potentials,P50 Evoked Potentials,P50 Wave,P600 Evoked Potentials,Potentials, Event-Related,Event Related Potentials,Event-Related Potential,Evoked Potential, N100,Evoked Potential, N200,Evoked Potential, N300,Evoked Potential, N400,Evoked Potential, P200,Evoked Potential, P50,Evoked Potential, P600,Evoked Potentials, N100,Evoked Potentials, N200,Evoked Potentials, N300,Evoked Potentials, N400,Evoked Potentials, P200,Evoked Potentials, P50,Evoked Potentials, P600,N1 Waves,N2 Waves,N200 Evoked Potential,N3 Waves,N300 Evoked Potential,N4 Waves,N400 Evoked Potential,P2 Waves,P200 Evoked Potential,P50 Waves,P600 Evoked Potential,Potential, Event Related,Potential, Event-Related,Potential, Evoked,Potentials, Event Related,Potentials, Evoked,Potentials, N400 Evoked,Related Potential, Event,Related Potentials, Event,Wave, N1,Wave, N2,Wave, N3,Wave, N4,Wave, P2,Wave, P50,Waves, N1,Waves, N2,Waves, N3,Waves, N4,Waves, P2,Waves, P50
D005149 Facial Expression Observable changes of expression in the face in response to emotional stimuli. Face Expression,Expression, Face,Expression, Facial,Face Expressions,Facial Expressions
D006801 Humans Members of the species Homo sapiens. Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D012559 Schizophrenia A severe emotional disorder of psychotic depth characteristically marked by a retreat from reality with delusion formation, HALLUCINATIONS, emotional disharmony, and regressive behavior. Dementia Praecox,Schizophrenic Disorders,Disorder, Schizophrenic,Disorders, Schizophrenic,Schizophrenias,Schizophrenic Disorder
D012565 Schizophrenic Psychology Study of mental processes and behavior of schizophrenics. Psychology, Schizophrenic

Related Publications

Amanda McCleery, and Junghee Lee, and Aditi Joshi, and Jonathan K Wynn, and Gerhard S Hellemann, and Michael F Green
March 2005, Psychiatry research,
Amanda McCleery, and Junghee Lee, and Aditi Joshi, and Jonathan K Wynn, and Gerhard S Hellemann, and Michael F Green
July 1999, Psychophysiology,
Amanda McCleery, and Junghee Lee, and Aditi Joshi, and Jonathan K Wynn, and Gerhard S Hellemann, and Michael F Green
January 2015, Behavioural neurology,
Amanda McCleery, and Junghee Lee, and Aditi Joshi, and Jonathan K Wynn, and Gerhard S Hellemann, and Michael F Green
January 1990, Psychiatric medicine,
Amanda McCleery, and Junghee Lee, and Aditi Joshi, and Jonathan K Wynn, and Gerhard S Hellemann, and Michael F Green
January 2009, International journal of psychophysiology : official journal of the International Organization of Psychophysiology,
Amanda McCleery, and Junghee Lee, and Aditi Joshi, and Jonathan K Wynn, and Gerhard S Hellemann, and Michael F Green
April 2012, International journal of psychophysiology : official journal of the International Organization of Psychophysiology,
Amanda McCleery, and Junghee Lee, and Aditi Joshi, and Jonathan K Wynn, and Gerhard S Hellemann, and Michael F Green
January 1988, Schizophrenia bulletin,
Amanda McCleery, and Junghee Lee, and Aditi Joshi, and Jonathan K Wynn, and Gerhard S Hellemann, and Michael F Green
January 2023, Frontiers in human neuroscience,
Amanda McCleery, and Junghee Lee, and Aditi Joshi, and Jonathan K Wynn, and Gerhard S Hellemann, and Michael F Green
January 2000, Acta neurobiologiae experimentalis,
Amanda McCleery, and Junghee Lee, and Aditi Joshi, and Jonathan K Wynn, and Gerhard S Hellemann, and Michael F Green
January 1985, Seishin shinkeigaku zasshi = Psychiatria et neurologia Japonica,
Copied contents to your clipboard!