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Today, the 'obesity pandemic' is one of the biggest health issues around the world. Melanin-concentrating hormone (MCH), a hypothalamic neuropeptide, is one of the most potent, central stimulators of feeding and it also attenuates energy expenditure. Inhibitions of the MCH receptor, the melanin-concentrating hormone receptor-1 (MCHR1), has attracted considerable attention as a potential anti-obesity drug, during the last decade. Now, there are a large number of MCHR1 antagonists, pharmacological tools and clinical drug candidates that can provide clues to develop new structures with high potency and good pharmacokinetic profile. The function of MCHR1 in energy homeostasis, obesity, metabolic syndrome, mood disorders and inflammatory bowel disease is discussed. Relevant clinical trials and patent background information of the MCHR1 antagonists over the last 4 years are also reviewed.
Katalin K Szalai, and
Gyula Beke, and
János Éles, and
Tamás Kitka, and
Péter Kovács, and
József Nagy, and
Sándor Farkas, and
András Boros
February 2015,
Expert opinion on therapeutic patents,
Katalin K Szalai, and
Gyula Beke, and
János Éles, and
Tamás Kitka, and
Péter Kovács, and
József Nagy, and
Sándor Farkas, and
András Boros
October 2014,
Mini reviews in medicinal chemistry,
Katalin K Szalai, and
Gyula Beke, and
János Éles, and
Tamás Kitka, and
Péter Kovács, and
József Nagy, and
Sándor Farkas, and
András Boros
October 2003,
Current opinion in investigational drugs (London, England : 2000),
Katalin K Szalai, and
Gyula Beke, and
János Éles, and
Tamás Kitka, and
Péter Kovács, and
József Nagy, and
Sándor Farkas, and
András Boros
January 2010,
Recent patents on CNS drug discovery,
Katalin K Szalai, and
Gyula Beke, and
János Éles, and
Tamás Kitka, and
Péter Kovács, and
József Nagy, and
Sándor Farkas, and
András Boros
January 2007,
Current topics in medicinal chemistry,
Katalin K Szalai, and
Gyula Beke, and
János Éles, and
Tamás Kitka, and
Péter Kovács, and
József Nagy, and
Sándor Farkas, and
András Boros
January 2020,
Recent patents on anti-cancer drug discovery,
Katalin K Szalai, and
Gyula Beke, and
János Éles, and
Tamás Kitka, and
Péter Kovács, and
József Nagy, and
Sándor Farkas, and
András Boros
February 2005,
Bioorganic & medicinal chemistry letters,
Katalin K Szalai, and
Gyula Beke, and
János Éles, and
Tamás Kitka, and
Péter Kovács, and
József Nagy, and
Sándor Farkas, and
András Boros
January 1992,
Journal of neural transmission. Supplementum,
Katalin K Szalai, and
Gyula Beke, and
János Éles, and
Tamás Kitka, and
Péter Kovács, and
József Nagy, and
Sándor Farkas, and
András Boros
January 2005,
Current topics in medicinal chemistry,
Katalin K Szalai, and
Gyula Beke, and
János Éles, and
Tamás Kitka, and
Péter Kovács, and
József Nagy, and
Sándor Farkas, and
András Boros
January 2000,
Neurologia i neurochirurgia polska,
