Craniofacial morphology and asymmetry were compared before, during, and after puberty within and between patients with unilateral complete cleft lip and palate (UCCLP) and a non-cleft group. In the UCCLP group, the posterior cranial base and total cranial base were significantly shorter at all skeletal periods, the maxilla was significantly retruded and posteriorly rotated, and the mandible was significantly smaller and inferoposteriorly rotated. The angle between the nasal and mandibular plane and lower anterior facial height were significantly higher, and upper posterior facial height and total posterior height were significantly lower, in the UCCLP group. Except for an increase in the nasal cavity, no significant differences were detected in facial width. For all measurements, asymmetry on the horizontal plane was more significant than that on the vertical plane. Asymmetries in the UCCLP group were mostly detected during puberty. The UCCLP group had no distinctive mandibular asymmetry, as compared with the Class I group. In UCCLP patients, the cranial base, maxilla, and mandible were affected on the sagittal plane during all growth periods. However, horizontal asymmetries were mostly detected before and during puberty. Vertical asymmetries were less severe, and there was no distinctive mandibular asymmetry as compared with the Class I group. (J Oral Sci 56, 165-172, 2014).