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It is well-established that the anesthetic requirement (MAC) of volatile agents such as halothane is reduced in elderly patients. The current project was designed to determine whether a similar alteration in anesthetic requirement occurs in Fischer-344 (F-344) rats, an animal model often utilized in physiology and pharmacology to examine aging-related changes. Animals were exposed to increasing or decreasing levels of halothane. After equilibration at each concentration, the response to tail-clamping was used for MAC testing. MAC was reduced approximately 17% in aged (25 months) versus young adult (5 months) animals. From these data, it is concluded that the F-344 rat may be an adequate model for examination of age-dependent alterations in the actions of volatile anesthetics.
G E Loss, and
E Seifen, and
R H Kennedy, and
A B Seifen
May 2003,
Anesthesia and analgesia,
G E Loss, and
E Seifen, and
R H Kennedy, and
A B Seifen
November 1999,
British journal of anaesthesia,
G E Loss, and
E Seifen, and
R H Kennedy, and
A B Seifen
February 1975,
Anesthesiology,
G E Loss, and
E Seifen, and
R H Kennedy, and
A B Seifen
October 1990,
Anesthesiology,
G E Loss, and
E Seifen, and
R H Kennedy, and
A B Seifen
September 1989,
Anesthesiology,
G E Loss, and
E Seifen, and
R H Kennedy, and
A B Seifen
April 1997,
Anesthesia and analgesia,
G E Loss, and
E Seifen, and
R H Kennedy, and
A B Seifen
November 1989,
Laboratory animal science,
G E Loss, and
E Seifen, and
R H Kennedy, and
A B Seifen
November 1983,
Anesthesiology,
G E Loss, and
E Seifen, and
R H Kennedy, and
A B Seifen
March 1987,
Toxicology and applied pharmacology,
G E Loss, and
E Seifen, and
R H Kennedy, and
A B Seifen
March 1975,
British journal of anaesthesia,
