OBJECTIVE Severely fluorosed and heavily discolored teeth that have large enamel defects give rise to esthetic concerns and require permanent treatment. In such cases, restorative techniques such as porcelain or composite laminate veneers or crowns are generally preferred, in which tooth preparation is inevitably required. METHODS This clinical report describes a patient with severely fluorosed teeth who was successfully treated with a minimally invasive technique including enamel microabrasion (6.6% hydrochloric acid slurry with silicon carbide micro-particles, Opalustre, Ultradent Products, Inc., South Jordan, UT, USA) followed by in-office bleaching (38% hydrogen peroxide, Opalescence Boost, Ultradent). Enamel microabrasion was conducted in two visits while three visits were required for in-office bleaching. Patient was followed-up after 2 years. RESULTS A slight staining had occurred during this period, but it was acceptable for patient. No adverse effects were observed. CONCLUSIONS The minimally invasive technique including enamel microabrasion and in-office bleaching was efficient and may represent a good alternative to traditional restorative techniques for the management of severely fluorosed teeth.