Recent advances in imaging technology have created new opportunities for medical imaging to improve health care in resource-restricted countries around the world. Radiology residents are increasingly interested in global health and imaging outreach, yet infrastructure and opportunities for international outreach are limited. With the recent change in the ABR exam schedule, residents now have more flexibility in the fourth year of training to pursue elective interests, including participation in global health projects. Creating a formalized global health imaging curriculum will improve the quality, quantity, and overall impact of initiatives undertaken by residents and their training programs. A curriculum is proposed that provides content, opportunities for global health project development, and established metrics for effective evaluation and assessment. Four components considered integral to a global health imaging curriculum are described: (1) global and public health education; (2) targeted travel medicine education; (3) basic imaging proficiency; and (4) practice attitudes and accountability. Methods are presented of differentiating curricula to increase applicability across the spectrum of training programs that vary in available resources. A blueprint is presented for formalizing a global health curriculum or elective rotation within a program, as well as a resource for residents, radiologists, and organizations to make a meaningful impact on global health.