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Of the first 250 heart and 35 heart and lung transplant recipients at Papworth Hospital, Cambridge, who survived for more than one month after transplantation, 217 heart and 33 heart and lung patients were investigated serologically for evidence of Toxoplasma gondii infection. Six patients acquired primary T gondii infection, most probably from the donor organ. Five patients experienced T gondii recrudescence, two of whom had recovered from primary infection a few years earlier. Two patients died from primary T gondii infection and the severity of symptoms in the other patients with primary infection was related to the amount of immunosuppressive treatment. Prophylaxis with pyrimethamine (25 mg a day for six weeks) was introduced for T gondii antibody negative transplant recipients who received a heart from a T gondii antibody positive donor after the first four cases of primary toxoplasmosis. Of the seven patients not given pyrimethamine, four (57%) acquired primary T gondii infection. This compared with two of the 14 patients (14%) given prophylaxis.
T G Wreghitt, and
M Hakim, and
J J Gray, and
A H Balfour, and
P G Stovin, and
S Stewart, and
J Scott, and
T A English, and
J Wallwork
May 1996,
European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology,
T G Wreghitt, and
M Hakim, and
J J Gray, and
A H Balfour, and
P G Stovin, and
S Stewart, and
J Scott, and
T A English, and
J Wallwork
January 1992,
Scandinavian journal of infectious diseases,
T G Wreghitt, and
M Hakim, and
J J Gray, and
A H Balfour, and
P G Stovin, and
S Stewart, and
J Scott, and
T A English, and
J Wallwork
May 1998,
Acta obstetricia et gynecologica Scandinavica,
T G Wreghitt, and
M Hakim, and
J J Gray, and
A H Balfour, and
P G Stovin, and
S Stewart, and
J Scott, and
T A English, and
J Wallwork
June 1986,
Transplantation,
T G Wreghitt, and
M Hakim, and
J J Gray, and
A H Balfour, and
P G Stovin, and
S Stewart, and
J Scott, and
T A English, and
J Wallwork
February 2012,
Clinical microbiology newsletter,
T G Wreghitt, and
M Hakim, and
J J Gray, and
A H Balfour, and
P G Stovin, and
S Stewart, and
J Scott, and
T A English, and
J Wallwork
January 2019,
Critical care clinics,
T G Wreghitt, and
M Hakim, and
J J Gray, and
A H Balfour, and
P G Stovin, and
S Stewart, and
J Scott, and
T A English, and
J Wallwork
March 2024,
Infectious disease clinics of North America,
T G Wreghitt, and
M Hakim, and
J J Gray, and
A H Balfour, and
P G Stovin, and
S Stewart, and
J Scott, and
T A English, and
J Wallwork
April 2003,
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America,
T G Wreghitt, and
M Hakim, and
J J Gray, and
A H Balfour, and
P G Stovin, and
S Stewart, and
J Scott, and
T A English, and
J Wallwork
June 1989,
The Journal of antimicrobial chemotherapy,
T G Wreghitt, and
M Hakim, and
J J Gray, and
A H Balfour, and
P G Stovin, and
S Stewart, and
J Scott, and
T A English, and
J Wallwork
May 1995,
Chest,
