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Intrinsically germanium-69-labeled iron oxide nanoparticles: synthesis and in-vivo dual-modality PET/MR imaging. 2014
Rubel Chakravarty, and
Hector F Valdovinos, and
Feng Chen, and
Christina M Lewis, and
Paul A Ellison, and
Haiming Luo, and
M Elizabeth Meyerand, and
Robert J Nickles, and
Weibo Cai
Department of Radiology, University of Wisconsin - Madison, Madison, WI, USA; Isotope Applications and Radiopharmaceuticals Division, Bhabha Atomic Research Centre, Mumbai, India.
Intrinsically germanium-69-labeled super-paramagnetic iron oxide nanoparticles are synthesized via a newly developed, fast and highly specific chelator-free approach. The biodistribution pattern and the feasibility of (69) Ge-SPION@PEG for in vivo dual-modality positron emission tomography/magnetic resonance (PET/MR) imaging and lymph-node mapping are investigated, which represents the first example of the successful utilization of a (69) Ge-based agent for PET/MR imaging.
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