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Silver binding nucleolar organizer regions dots in oral leukoplakia with epithelial dysplasia and oral squamous cell carcinoma: an in vivo study. 2014
Fahad Mansoor Samadi, and
Bastain Thattil Sebastian, and
Anil Singh, and
Shaleen Chandra, and
Shadab Mohammad, and
Arun Singh, and
Thippeswamy Halappa, and
Firoza Samadi
Department of Oral Pathology & Microbiology, King George's Medical University, Lucknow, India.
Silver binding nucleolar organizer regions (AgNOR) in normal oral mucosa (NOM), oral leukoplakia with epithelial dysplasia (ED), and oral squamous cell carcinoma (OSCC) were studied. The mean AgNOR count per nucleus increased from NOM to ED to OSCC. Tissue showing ED in oral leukoplakia and OSCC cases showed higher counts, wider scatter, and smaller size of AgNOR dots in the nuclei. The study seems to suggest that time method has some potential in distinguishing between NOM and oral leukoplakia with ED and OSCC. Studies of larger numbers are needed to arrive at more substantial conclusions.
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