The effect of selective serotonin re-uptake inhibitors (SSRIs) on seizure duration during a course of electroconvulsive therapy (ECT) was evaluated in a retrospective study. Although numbers in the SSRI group were small (n=13), there was a significantly longer seizure duration with SSRIs, compared with tricyclic antidepressants (TCAs) and monoamine oxidase inhibitors (MAOIs). More studies are needed to see whether this is a general finding or whether it reflects individual variation, and most importantly, what effects, if any, this has on clinical outcome.