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The metabolic effects of sodium valproate (VPA) on rat renal cortical tubules have been examined. When 1 or 5 mM lactate was used as substrate in the incubation medium, VPA decreased markedly the lactate uptake by the tubules. When 1 or 5 mM glutamine was used, the addition of VPA accelerated glutamine uptake, ammoniagenesis, but also stimulated markedly the accumulation of lactate and pyruvate produced from glutamine. VPA had a dose-dependent inhibitory effect on gluconeogenesis from both glutamine and lactate. With 5 mM glutamine, VPA also induced a significant accumulation of glutamate in the medium. The oxygen consumption by the tubules was diminished by 40% following VPA addition. It is concluded that VPA modifies the metabolism of rat cortical tubules by interfering with the oxidation of natural substrates and stimulates in this fashion the production of ammonia by kidney tubules.
M Doval, and
M Culebras, and
A Lopez-Farré, and
M Rengel, and
A Gougoux, and
P Vinay, and
J M Lopez-Novoa
January 1993,
Archives internationales de physiologie, de biochimie et de biophysique,
M Doval, and
M Culebras, and
A Lopez-Farré, and
M Rengel, and
A Gougoux, and
P Vinay, and
J M Lopez-Novoa
February 1989,
Canadian journal of physiology and pharmacology,
M Doval, and
M Culebras, and
A Lopez-Farré, and
M Rengel, and
A Gougoux, and
P Vinay, and
J M Lopez-Novoa
January 1985,
Contributions to nephrology,
M Doval, and
M Culebras, and
A Lopez-Farré, and
M Rengel, and
A Gougoux, and
P Vinay, and
J M Lopez-Novoa
September 1984,
Biochimica et biophysica acta,
M Doval, and
M Culebras, and
A Lopez-Farré, and
M Rengel, and
A Gougoux, and
P Vinay, and
J M Lopez-Novoa
March 1990,
Biochimica et biophysica acta,
M Doval, and
M Culebras, and
A Lopez-Farré, and
M Rengel, and
A Gougoux, and
P Vinay, and
J M Lopez-Novoa
September 1979,
European journal of biochemistry,
M Doval, and
M Culebras, and
A Lopez-Farré, and
M Rengel, and
A Gougoux, and
P Vinay, and
J M Lopez-Novoa
January 1980,
The International journal of biochemistry,
M Doval, and
M Culebras, and
A Lopez-Farré, and
M Rengel, and
A Gougoux, and
P Vinay, and
J M Lopez-Novoa
October 1999,
Biochemical pharmacology,
M Doval, and
M Culebras, and
A Lopez-Farré, and
M Rengel, and
A Gougoux, and
P Vinay, and
J M Lopez-Novoa
November 1989,
Biochemical pharmacology,
M Doval, and
M Culebras, and
A Lopez-Farré, and
M Rengel, and
A Gougoux, and
P Vinay, and
J M Lopez-Novoa
July 1980,
The Biochemical journal,
