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The effect of valproic acid on the distribution of gavaged 65Zn in maternal and embryonic tissue of Sprague-Dawley rats was examined 24 h after gavaging of the drug on d 13 of pregnancy. Valproic acid treatment resulted in a significantly higher retention of 65Zn in maternal liver and lower amounts in uterus, placenta and embryos than in controls. Compared to controls, gel chromatography of maternal liver from valproic acid-treated dams showed higher 65Zn counts associated with a protein peak of molecular weight of 6,500, the approximate molecular weight of the Zn-binding protein metallothionein. These results support the idea that the teratogenicity of valproic acid is in part due to an induction of embryonic Zn deficiency secondary to a drug-induced sequestering of Zn into maternal liver that results in a decrease in maternal plasma Zn and subsequent reduction in embryonic Zn uptake.
C L Keen, and
J M Peters, and
L S Hurley
April 1989,
Teratology,
C L Keen, and
J M Peters, and
L S Hurley
March 1994,
Physiology & behavior,
C L Keen, and
J M Peters, and
L S Hurley
July 1979,
Indian journal of experimental biology,
C L Keen, and
J M Peters, and
L S Hurley
December 1984,
Toxicology letters,
C L Keen, and
J M Peters, and
L S Hurley
January 1981,
Hepatology (Baltimore, Md.),
C L Keen, and
J M Peters, and
L S Hurley
February 1988,
Rivista europea per le scienze mediche e farmacologiche = European review for medical and pharmacological sciences = Revue europeenne pour les sciences medicales et pharmacologiques,
C L Keen, and
J M Peters, and
L S Hurley
December 1979,
The Journal of pharmacology and experimental therapeutics,
C L Keen, and
J M Peters, and
L S Hurley
February 1999,
Pharmaceutica acta Helvetiae,
C L Keen, and
J M Peters, and
L S Hurley
January 1980,
Pediatric pharmacology (New York, N.Y.),
C L Keen, and
J M Peters, and
L S Hurley
November 1966,
The Journal of nutrition,
