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Amygdala Atrophy in MCI/Alzheimer's Disease in the BIOCARD cohort based on Diffeomorphic Morphometry. 2012
Michael I Miller, and
Laurent Younes, and
J Tilak Ratnanather, and
Timothy Brown, and
Tommy Reigel, and
Huong Trinh, and
Xiaoying Tang, and
Peter Barker, and
Susumu Mori, and
Marilyn Albert
Center for Imaging Science, Johns Hopkins University.
Surface-based deformation markers obtained from diffeomorphic mapping of the amygdala are used to study specific atrophy patterns in a combined mild cognitively impaired and demented cohort compared with cognitively normal aging subjects. Statistical analysis demonstrates with high significance in a small sample of legacy data that deformation-based morphometry provides sensitive markers for locating atrophy in the amygdala. With respect to a high-field amygdala atlas, significant atrophy was found in the basomedial and lateral nucleus subregions.
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