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Thirty-five patients with a median age of 55 years (range, 28 to 68 years) and a median Karnofsky status of 80% (range, 40% to 100%) were treated with ifosfamide (1.5 g/m2 plus mesna), methotrexate (40 mg/m2), and 5-fluorouracil (600 mg/m2) intravenously (IV) days 1 and 8 at intervals of 4 weeks. Thirty-four patients had received previous chemotherapy, including anthracyclines in 28 patients. All patients were evaluable for response. A partial remission was achieved in six patients (17%), stable disease in 13 patients (37%), and 16 patients (46%) were unresponsive. Median time to progression was 7 months (range, 4 to 13 months) for partial responders, and 4 months for patients with stable disease. Median survival was 9 months for all patients, 13 months for partial responders, 16 months for no change, and 3 months for progressive disease. Toxicity was tolerable, with myelotoxicity being a dose-limiting factor, mainly in heavily pretreated patients. No treatment-related death occurred. In conclusion, this combination is effective and well tolerated. Ifosfamide is suggested for further evaluation in advanced breast cancer.
R Becher, and
H Höfeler, and
O Kloke, and
E Kurschel, and
R B Schilcher, and
O Weinhardt, and
U Wandl, and
C G Schmidt
January 1990,
Cancer chemotherapy and pharmacology,
R Becher, and
H Höfeler, and
O Kloke, and
E Kurschel, and
R B Schilcher, and
O Weinhardt, and
U Wandl, and
C G Schmidt
January 1995,
Anticancer research,
R Becher, and
H Höfeler, and
O Kloke, and
E Kurschel, and
R B Schilcher, and
O Weinhardt, and
U Wandl, and
C G Schmidt
January 1998,
La Clinica terapeutica,
R Becher, and
H Höfeler, and
O Kloke, and
E Kurschel, and
R B Schilcher, and
O Weinhardt, and
U Wandl, and
C G Schmidt
June 1983,
Seminars in oncology,
R Becher, and
H Höfeler, and
O Kloke, and
E Kurschel, and
R B Schilcher, and
O Weinhardt, and
U Wandl, and
C G Schmidt
December 1989,
The Netherlands journal of medicine,
R Becher, and
H Höfeler, and
O Kloke, and
E Kurschel, and
R B Schilcher, and
O Weinhardt, and
U Wandl, and
C G Schmidt
January 1981,
Medicina,
R Becher, and
H Höfeler, and
O Kloke, and
E Kurschel, and
R B Schilcher, and
O Weinhardt, and
U Wandl, and
C G Schmidt
February 1996,
Journal of chemotherapy (Florence, Italy),
R Becher, and
H Höfeler, and
O Kloke, and
E Kurschel, and
R B Schilcher, and
O Weinhardt, and
U Wandl, and
C G Schmidt
February 1979,
Tumori,
R Becher, and
H Höfeler, and
O Kloke, and
E Kurschel, and
R B Schilcher, and
O Weinhardt, and
U Wandl, and
C G Schmidt
January 1991,
Journal of surgical oncology. Supplement,
R Becher, and
H Höfeler, and
O Kloke, and
E Kurschel, and
R B Schilcher, and
O Weinhardt, and
U Wandl, and
C G Schmidt
January 1990,
British journal of cancer,
