Staphylococcal enterotoxins stimulate lymphoma-associated immune dysregulation. 2014

Thorbjørn Krejsgaard, and Andreas Willerslev-Olsen, and Lise M Lindahl, and Charlotte M Bonefeld, and Sergei B Koralov, and Carsten Geisler, and Mariusz A Wasik, and Robert Gniadecki, and Mogens Kilian, and Lars Iversen, and Anders Woetmann, and Niels Odum
Department of International Health, Immunology and Microbiology, University of Copenhagen, Copenhagen, Denmark;

Patients with cutaneous T-cell lymphoma (CTCL) are frequently colonized with Staphylococcus aureus (SA). Eradication of SA is, importantly, associated with significant clinical improvement, suggesting that SA promotes the disease activity, but the underlying mechanisms remain poorly characterized. Here, we show that SA isolates from involved skin express staphylococcal enterotoxins (SEs) that induce crosstalk between malignant and benign T cells leading to Stat3-mediated interleukin-10 (IL-10) production by the malignant T cells. The SEs did not stimulate the malignant T cells directly. Instead, SEs triggered a cascade of events involving cell-cell and asymmetric cytokine interactions between malignant and benign T cells, which stimulated the malignant T cells to express high levels of IL-10. Much evidence supports that malignant activation of the Stat3/IL-10 axis plays a key role in driving the immune dysregulation and severe immunodeficiency that characteristically develops in CTCL patients. The present findings thereby establish a novel link between SEs and immune dysregulation in CTCL, strengthening the rationale for antibiotic treatment of colonized patients with severe or progressive disease.

UI MeSH Term Description Entries
D008213 Lymphocyte Activation Morphologic alteration of small B LYMPHOCYTES or T LYMPHOCYTES in culture into large blast-like cells able to synthesize DNA and RNA and to divide mitotically. It is induced by INTERLEUKINS; MITOGENS such as PHYTOHEMAGGLUTININS, and by specific ANTIGENS. It may also occur in vivo as in GRAFT REJECTION. Blast Transformation,Blastogenesis,Lymphoblast Transformation,Lymphocyte Stimulation,Lymphocyte Transformation,Transformation, Blast,Transformation, Lymphoblast,Transformation, Lymphocyte,Activation, Lymphocyte,Stimulation, Lymphocyte
D008297 Male Males
D004768 Enterotoxins Substances that are toxic to the intestinal tract causing vomiting, diarrhea, etc.; most common enterotoxins are produced by bacteria. Staphylococcal Enterotoxin,Enterotoxin,Staphylococcal Enterotoxins,Enterotoxin, Staphylococcal,Enterotoxins, Staphylococcal
D005260 Female Females
D006801 Humans Members of the species Homo sapiens. Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D001426 Bacterial Proteins Proteins found in any species of bacterium. Bacterial Gene Products,Bacterial Gene Proteins,Gene Products, Bacterial,Bacterial Gene Product,Bacterial Gene Protein,Bacterial Protein,Gene Product, Bacterial,Gene Protein, Bacterial,Gene Proteins, Bacterial,Protein, Bacterial,Proteins, Bacterial
D013203 Staphylococcal Infections Infections with bacteria of the genus STAPHYLOCOCCUS. Infections, Staphylococcal,Staphylococcus aureus Infection,Staphylococcal Infection,Staphylococcus aureus Infections
D013211 Staphylococcus aureus Potentially pathogenic bacteria found in nasal membranes, skin, hair follicles, and perineum of warm-blooded animals. They may cause a wide range of infections and intoxications.
D013601 T-Lymphocytes Lymphocytes responsible for cell-mediated immunity. Two types have been identified - cytotoxic (T-LYMPHOCYTES, CYTOTOXIC) and helper T-lymphocytes (T-LYMPHOCYTES, HELPER-INDUCER). They are formed when lymphocytes circulate through the THYMUS GLAND and differentiate to thymocytes. When exposed to an antigen, they divide rapidly and produce large numbers of new T cells sensitized to that antigen. T Cell,T Lymphocyte,T-Cells,Thymus-Dependent Lymphocytes,Cell, T,Cells, T,Lymphocyte, T,Lymphocyte, Thymus-Dependent,Lymphocytes, T,Lymphocytes, Thymus-Dependent,T Cells,T Lymphocytes,T-Cell,T-Lymphocyte,Thymus Dependent Lymphocytes,Thymus-Dependent Lymphocyte
D016410 Lymphoma, T-Cell, Cutaneous A group of lymphomas exhibiting clonal expansion of malignant T-lymphocytes arrested at varying stages of differentiation as well as malignant infiltration of the skin. MYCOSIS FUNGOIDES; SEZARY SYNDROME; LYMPHOMATOID PAPULOSIS; and PRIMARY CUTANEOUS ANAPLASTIC LARGE CELL LYMPHOMA are the best characterized of these disorders. Granulomatous Slack Skin,T-Cell Lymphoma, Cutaneous,Cutaneous T-Cell Lymphoma,Lymphoma, T Cell, Cutaneous,Cutaneous T Cell Lymphoma,Cutaneous T-Cell Lymphomas,Lymphoma, Cutaneous T-Cell,Lymphomas, Cutaneous T-Cell,Slack Skin, Granulomatous,T Cell Lymphoma, Cutaneous,T-Cell Lymphomas, Cutaneous

Related Publications

Thorbjørn Krejsgaard, and Andreas Willerslev-Olsen, and Lise M Lindahl, and Charlotte M Bonefeld, and Sergei B Koralov, and Carsten Geisler, and Mariusz A Wasik, and Robert Gniadecki, and Mogens Kilian, and Lars Iversen, and Anders Woetmann, and Niels Odum
June 1991, FEMS microbiology immunology,
Thorbjørn Krejsgaard, and Andreas Willerslev-Olsen, and Lise M Lindahl, and Charlotte M Bonefeld, and Sergei B Koralov, and Carsten Geisler, and Mariusz A Wasik, and Robert Gniadecki, and Mogens Kilian, and Lars Iversen, and Anders Woetmann, and Niels Odum
January 1983, Voprosy pitaniia,
Thorbjørn Krejsgaard, and Andreas Willerslev-Olsen, and Lise M Lindahl, and Charlotte M Bonefeld, and Sergei B Koralov, and Carsten Geisler, and Mariusz A Wasik, and Robert Gniadecki, and Mogens Kilian, and Lars Iversen, and Anders Woetmann, and Niels Odum
January 1968, Revista de sanidad e higiene publica,
Thorbjørn Krejsgaard, and Andreas Willerslev-Olsen, and Lise M Lindahl, and Charlotte M Bonefeld, and Sergei B Koralov, and Carsten Geisler, and Mariusz A Wasik, and Robert Gniadecki, and Mogens Kilian, and Lars Iversen, and Anders Woetmann, and Niels Odum
August 2010, Toxins,
Thorbjørn Krejsgaard, and Andreas Willerslev-Olsen, and Lise M Lindahl, and Charlotte M Bonefeld, and Sergei B Koralov, and Carsten Geisler, and Mariusz A Wasik, and Robert Gniadecki, and Mogens Kilian, and Lars Iversen, and Anders Woetmann, and Niels Odum
October 2000, International journal of food microbiology,
Thorbjørn Krejsgaard, and Andreas Willerslev-Olsen, and Lise M Lindahl, and Charlotte M Bonefeld, and Sergei B Koralov, and Carsten Geisler, and Mariusz A Wasik, and Robert Gniadecki, and Mogens Kilian, and Lars Iversen, and Anders Woetmann, and Niels Odum
January 1985, Revista de igiena, bacteriologie, virusologie, parazitologie, epidemiologie, pneumoftiziologie. Bacteriologia, virusologia, parazitologia, epidemiologia,
Thorbjørn Krejsgaard, and Andreas Willerslev-Olsen, and Lise M Lindahl, and Charlotte M Bonefeld, and Sergei B Koralov, and Carsten Geisler, and Mariusz A Wasik, and Robert Gniadecki, and Mogens Kilian, and Lars Iversen, and Anders Woetmann, and Niels Odum
July 2010, Toxins,
Thorbjørn Krejsgaard, and Andreas Willerslev-Olsen, and Lise M Lindahl, and Charlotte M Bonefeld, and Sergei B Koralov, and Carsten Geisler, and Mariusz A Wasik, and Robert Gniadecki, and Mogens Kilian, and Lars Iversen, and Anders Woetmann, and Niels Odum
December 1967, Japanese journal of microbiology,
Thorbjørn Krejsgaard, and Andreas Willerslev-Olsen, and Lise M Lindahl, and Charlotte M Bonefeld, and Sergei B Koralov, and Carsten Geisler, and Mariusz A Wasik, and Robert Gniadecki, and Mogens Kilian, and Lars Iversen, and Anders Woetmann, and Niels Odum
August 1964, Turk Tip Cemiyeti mecmuasi,
Thorbjørn Krejsgaard, and Andreas Willerslev-Olsen, and Lise M Lindahl, and Charlotte M Bonefeld, and Sergei B Koralov, and Carsten Geisler, and Mariusz A Wasik, and Robert Gniadecki, and Mogens Kilian, and Lars Iversen, and Anders Woetmann, and Niels Odum
March 2013, Military medicine,
Copied contents to your clipboard!