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Recently, increased spontaneous chromosome instability was reported in couples with recurrent spontaneous abortions but without constitutional chromosome aberrations. Therefore, we investigated the frequency and distribution of aphidicolin-induced common fragile sites in couples with recurrent spontaneous abortions and no children and in age-related control couples. The breakage rate was significantly elevated in the abortion-prone couples; the women in the abortion couples had an especially higher breakage rate than the control women. Breakpoints cluster to those chromosome regions where common fragile sites have been localized. No preference of a particular common fragile site was demonstrated in the abortion couples. Our findings appear to support the hypothesis of increased chromosome instability in at least some couples with recurrent spontaneous abortions. As long as the nature of aphidicolin-induced common fragile sites is not completely understood, the significance of these findings remains unclear.
B Schlegelberger, and
K Gripp, and
W Grote
January 1991,
Genetic counseling (Geneva, Switzerland),
B Schlegelberger, and
K Gripp, and
W Grote
May 1995,
European journal of obstetrics, gynecology, and reproductive biology,
B Schlegelberger, and
K Gripp, and
W Grote
January 1997,
Revista de investigacion clinica; organo del Hospital de Enfermedades de la Nutricion,
B Schlegelberger, and
K Gripp, and
W Grote
August 2002,
Tissue antigens,
B Schlegelberger, and
K Gripp, and
W Grote
January 1984,
Gynecologic and obstetric investigation,
B Schlegelberger, and
K Gripp, and
W Grote
October 1982,
Nihon Sanka Fujinka Gakkai zasshi,
B Schlegelberger, and
K Gripp, and
W Grote
July 1980,
American journal of human genetics,
B Schlegelberger, and
K Gripp, and
W Grote
January 1984,
TSitologiia i genetika,
B Schlegelberger, and
K Gripp, and
W Grote
March 2014,
Andrologia,
B Schlegelberger, and
K Gripp, and
W Grote
August 2007,
International journal of immunogenetics,
