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1. Effects of Na+ and Ca2+ on Cd2+ uptake in the guinea-pig and rabbit aorta were investigated. 2. The Cd2+ fraction can be divided with EDTA and Zn2+. The EDTA fraction may be intracellular fraction and the Zn2+ fraction may be loosely bound to surface membrane. 3. In Na+ deficient solution the Zn2+ fraction was markedly increased and the EDTA fraction also increased while the external Ca2+ concentrations scarcely affect the Cd2+ contents in both fractions. 4. Cd2+ did not affect the cellular Na+ and K+ contents. 5. These results suggest that Na+ strongly relates with these fractions but Na+ pump does not contribute to these phenomena.
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