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Enantioselective phospha-Michael addition of diarylphosphines to β,γ-unsaturated α-ketoesters and amides. 2014

Renta Jonathan Chew, and Kai Yuan Teo, and Yinhua Huang, and Bin-Bin Li, and Yongxin Li, and Sumod A Pullarkat, and Pak-Hing Leung
Division of Chemistry and Biological Chemistry, School of Physical and Mathematical Sciences, Nanyang Technological University, Singapore 637371, Singapore. pakhing@ntu.edu.sg.

An enantioselective hydrophosphination of β,γ-unsaturated α-ketoesters and amides has been developed using a chiral palladacycle catalyst. Adducts can be obtained in excellent yields and enantioselectivities, providing direct access to chiral tertiary phosphines which are synthetically useful intermediates in the preparation of bidentate ligands.

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