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Elevated serum levels of intact parathyroid hormone (PTH) have been reported in severe versus mild biliary cirrhosis. The aim of this study was to determine whether hyperparathyroidism was present in severe liver disease on the basis of the inability of the liver to catabolize the hormone. Because biologic activity resides in the amino terminal, and amino terminal PTH determinations have not been routinely made in liver disease, it is possible that hyperparathyroidism was previously missed in these patients. Accordingly, we obtained fasting blood from 11 patients with severe liver disease and 8 age-matched controls. We measured intact, amino terminal, and mid-region PTH, vitamin D metabolites, bone gamma carboxyglutamic acid protein (BGP), ionized calcium, phosphorus, magnesium, and liver function tests. Serum levels of PTH were normal with all assays and 1,25(OH)2D levels were not elevated. These findings argue against the possibility that hyperparathyroidism plays a role in the pathogenesis of hepatic osteodystrophy.
G L Klein, and
D B Endres, and
J D Colonna, and
W E Berquist, and
L I Goldstein, and
R W Busuttil, and
L J Deftos
January 1960,
Lancet (London, England),
G L Klein, and
D B Endres, and
J D Colonna, and
W E Berquist, and
L I Goldstein, and
R W Busuttil, and
L J Deftos
June 1994,
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research,
G L Klein, and
D B Endres, and
J D Colonna, and
W E Berquist, and
L I Goldstein, and
R W Busuttil, and
L J Deftos
May 1984,
Annals of neurology,
G L Klein, and
D B Endres, and
J D Colonna, and
W E Berquist, and
L I Goldstein, and
R W Busuttil, and
L J Deftos
September 1992,
Digestive diseases and sciences,
G L Klein, and
D B Endres, and
J D Colonna, and
W E Berquist, and
L I Goldstein, and
R W Busuttil, and
L J Deftos
January 1982,
Nephron,
G L Klein, and
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L I Goldstein, and
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December 2022,
Journal of nephrology,
G L Klein, and
D B Endres, and
J D Colonna, and
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L I Goldstein, and
R W Busuttil, and
L J Deftos
April 2008,
Endocrine practice : official journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists,
G L Klein, and
D B Endres, and
J D Colonna, and
W E Berquist, and
L I Goldstein, and
R W Busuttil, and
L J Deftos
October 2009,
The Journal of rheumatology,
G L Klein, and
D B Endres, and
J D Colonna, and
W E Berquist, and
L I Goldstein, and
R W Busuttil, and
L J Deftos
December 2001,
Nephrology nursing journal : journal of the American Nephrology Nurses' Association,
G L Klein, and
D B Endres, and
J D Colonna, and
W E Berquist, and
L I Goldstein, and
R W Busuttil, and
L J Deftos
August 1988,
World journal of surgery,
