-transparent.png){kind=logo}
OBJECTIVE Fibulin-1 is a matricellular protein that plays important roles in motility inhibition in a variety of cells and blocks the proliferation of cultured neural stem cells. The biological function of fibulin-1 in the spinal cord has not been fully elucidated. METHODS To clarify the expressions and possible functions of fibulin-1 in spinal cord injury (SCI), we performed an acute spinal cord contusion injury model in adult rats. Our work studied the temporospatial expression patterns of fibulin-1. RESULTS Western blot analysis revealed that fibulin-1 levels significantly increased 5 days after spinal cord contusion. Immunohistochemistry confirmed an increased number of fibulin-1 immunopositive cells about 2 mm from the lesion site. Moreover, double immunofluorescence labeling suggested that these changes were especially prominent in neurons and microglia. CONCLUSIONS These findings suggest that fibulin-1 may be involved in neuronal apoptosis and microglial activation after SCI.
Guanhua Xu, and
Ying Cui, and
Lingling Wang, and
Jinlong Zhang, and
Aiguo Shen, and
Weidong Li, and
Guofeng Bao, and
Yuyu Sun, and
Zhiming Cui
April 2016,
Neuropeptides,
Guanhua Xu, and
Ying Cui, and
Lingling Wang, and
Jinlong Zhang, and
Aiguo Shen, and
Weidong Li, and
Guofeng Bao, and
Yuyu Sun, and
Zhiming Cui
December 2009,
Journal of neurotrauma,
Guanhua Xu, and
Ying Cui, and
Lingling Wang, and
Jinlong Zhang, and
Aiguo Shen, and
Weidong Li, and
Guofeng Bao, and
Yuyu Sun, and
Zhiming Cui
May 2013,
Molecular medicine reports,
Guanhua Xu, and
Ying Cui, and
Lingling Wang, and
Jinlong Zhang, and
Aiguo Shen, and
Weidong Li, and
Guofeng Bao, and
Yuyu Sun, and
Zhiming Cui
February 2008,
Journal of molecular neuroscience : MN,
Guanhua Xu, and
Ying Cui, and
Lingling Wang, and
Jinlong Zhang, and
Aiguo Shen, and
Weidong Li, and
Guofeng Bao, and
Yuyu Sun, and
Zhiming Cui
November 2012,
Biological trace element research,
Guanhua Xu, and
Ying Cui, and
Lingling Wang, and
Jinlong Zhang, and
Aiguo Shen, and
Weidong Li, and
Guofeng Bao, and
Yuyu Sun, and
Zhiming Cui
February 2014,
Neuroscience research,
Guanhua Xu, and
Ying Cui, and
Lingling Wang, and
Jinlong Zhang, and
Aiguo Shen, and
Weidong Li, and
Guofeng Bao, and
Yuyu Sun, and
Zhiming Cui
February 1999,
Journal of neurotrauma,
Guanhua Xu, and
Ying Cui, and
Lingling Wang, and
Jinlong Zhang, and
Aiguo Shen, and
Weidong Li, and
Guofeng Bao, and
Yuyu Sun, and
Zhiming Cui
October 2023,
International journal of spine surgery,
Guanhua Xu, and
Ying Cui, and
Lingling Wang, and
Jinlong Zhang, and
Aiguo Shen, and
Weidong Li, and
Guofeng Bao, and
Yuyu Sun, and
Zhiming Cui
September 2015,
Neurochemical research,
Guanhua Xu, and
Ying Cui, and
Lingling Wang, and
Jinlong Zhang, and
Aiguo Shen, and
Weidong Li, and
Guofeng Bao, and
Yuyu Sun, and
Zhiming Cui
February 2013,
Journal of molecular neuroscience : MN,
