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[Disseminated intravascular coagulation in solid tumours]. 2014
François Régis Ferrand, and
Carine Garcia-Hejl, and
Yassine Moussaid, and
Antoine Schernberg, and
François-Clément Bidard, and
Michel Pavic, and
Safia Khenifer, and
Annabelle Stoclin
Hôpital du Val-de-Grâce, département d'oncologie-radiothérapie, boulevard du Port-Royal, 75005 Paris, France, Institut Gustave Roussy, département d'anesthésie-réanimation, Villejuif, France.
Disseminated intravascular coagulation (DIC) is a complex abnormality of hemostasis with dramatic consequences and long described as associated with tumors. Yet the diagnosis and management of paraneoplastic DIC are poorly defined. The purpose of this paper is to review DIC associated with solid tumors, at the pathophysiological and therapeutic levels in particular. We also report data from a recent retrospective series of patients with DIC in the context of a solid tumor, to illustrate the epidemiological, clinical and prognostic.
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