-transparent.png){kind=logo}
Nucleoside 5'-triphosphates modified at sugar residues as substrates for DNA polymerase from the thermoacidophilic archaebacterium Sulfolobus acidocaldarius. 1989
D Z Chinchaladze, and
D A Prangishvili, and
A V Scamrov, and
R S Beabealashvili, and
N B Dyatkina, and
A A Krayevsky
Institute of Molecular Biology and Biological Physics, Georgian SSR Academy of Sciences, Tbilisi, U.S.S.R.
The ability of a wide variety of nucleoside 5'-triphosphates with modified sugar moiety to serve as substrates in DNA synthesis catalyzed by DNA polymerase A from the archaebacterium Sulfolobus acidocaldarius was studied. Most of the dNTP analogs tested are shown to be specific terminating substrates for the synthesis irreversibly blocking further elongation of a nascent chain. The most powerful inhibitors were found to be 3'-amino derivatives of deoxy and arabino nucleoside triphosphates, while specific reverse transcriptase inhibitors, 3'-azido and 3'-methoxy derivatives of dNTP, were found to be inactive.
Related Publications
D Z Chinchaladze, and
D A Prangishvili, and
A V Scamrov, and
R S Beabealashvili, and
N B Dyatkina, and
A A Krayevsky
June 1979,
European journal of biochemistry,
D Z Chinchaladze, and
D A Prangishvili, and
A V Scamrov, and
R S Beabealashvili, and
N B Dyatkina, and
A A Krayevsky
November 1985,
FEBS letters,
D Z Chinchaladze, and
D A Prangishvili, and
A V Scamrov, and
R S Beabealashvili, and
N B Dyatkina, and
A A Krayevsky
May 1987,
European journal of biochemistry,
D Z Chinchaladze, and
D A Prangishvili, and
A V Scamrov, and
R S Beabealashvili, and
N B Dyatkina, and
A A Krayevsky
October 1996,
Gene,
D Z Chinchaladze, and
D A Prangishvili, and
A V Scamrov, and
R S Beabealashvili, and
N B Dyatkina, and
A A Krayevsky
July 1985,
Nucleic acids research,
D Z Chinchaladze, and
D A Prangishvili, and
A V Scamrov, and
R S Beabealashvili, and
N B Dyatkina, and
A A Krayevsky
July 1985,
Biochimica et biophysica acta,
D Z Chinchaladze, and
D A Prangishvili, and
A V Scamrov, and
R S Beabealashvili, and
N B Dyatkina, and
A A Krayevsky
November 1986,
Biochimica et biophysica acta,
D Z Chinchaladze, and
D A Prangishvili, and
A V Scamrov, and
R S Beabealashvili, and
N B Dyatkina, and
A A Krayevsky
November 1986,
Biochimica et biophysica acta,
D Z Chinchaladze, and
D A Prangishvili, and
A V Scamrov, and
R S Beabealashvili, and
N B Dyatkina, and
A A Krayevsky
August 1987,
Journal of biochemistry,
D Z Chinchaladze, and
D A Prangishvili, and
A V Scamrov, and
R S Beabealashvili, and
N B Dyatkina, and
A A Krayevsky
January 1989,
European journal of biochemistry,
