-transparent.png){kind=logo}
Potential and limitations of genetic manipulation in animals. 2006
Gerard J O'Sullivan, and
Colm M O'Tuathaigh, and
Jeremiah J Clifford, and
Gillian F O'Meara, and
David T Croke, and
John L Waddington
Molecular & Cellular Therapeutics and Research Institute, Royal College of Surgeons in Ireland, St. Stephen's Green, Dublin 2, Ireland.
Over the last decade, sequencing and characterisation of the mouse genome has been accompanied by unparalleled advances in functional genomics. In the context of drug action, we analyse the strengths and limitations of classical mutagenesis and gene targeting techniques, as well as alternative approaches such as chemical mutagenesis, gene trap, recombineering, transposon-mediated mutagenesis, chromosomal engineering, viral transgenesis and RNA interference. This review also focuses on the emerging importance of genetic manipulation in other species and related logistical issues of experimental work using mutants.:
| UI | MeSH Term | Description | Entries |
|---|
Related Publications
Gerard J O'Sullivan, and
Colm M O'Tuathaigh, and
Jeremiah J Clifford, and
Gillian F O'Meara, and
David T Croke, and
John L Waddington
January 1985,
Between the species : a journal of ethics,
Gerard J O'Sullivan, and
Colm M O'Tuathaigh, and
Jeremiah J Clifford, and
Gillian F O'Meara, and
David T Croke, and
John L Waddington
June 1990,
Tijdschrift voor diergeneeskunde,
Gerard J O'Sullivan, and
Colm M O'Tuathaigh, and
Jeremiah J Clifford, and
Gillian F O'Meara, and
David T Croke, and
John L Waddington
March 2005,
Nihon rinsho. Japanese journal of clinical medicine,
Gerard J O'Sullivan, and
Colm M O'Tuathaigh, and
Jeremiah J Clifford, and
Gillian F O'Meara, and
David T Croke, and
John L Waddington
January 2001,
Theriogenology,
Gerard J O'Sullivan, and
Colm M O'Tuathaigh, and
Jeremiah J Clifford, and
Gillian F O'Meara, and
David T Croke, and
John L Waddington
January 2012,
Revista peruana de medicina experimental y salud publica,
Gerard J O'Sullivan, and
Colm M O'Tuathaigh, and
Jeremiah J Clifford, and
Gillian F O'Meara, and
David T Croke, and
John L Waddington
December 1989,
Molecular biology & medicine,
Gerard J O'Sullivan, and
Colm M O'Tuathaigh, and
Jeremiah J Clifford, and
Gillian F O'Meara, and
David T Croke, and
John L Waddington
January 1980,
The British veterinary journal,
Gerard J O'Sullivan, and
Colm M O'Tuathaigh, and
Jeremiah J Clifford, and
Gillian F O'Meara, and
David T Croke, and
John L Waddington
February 1982,
Tijdschrift voor diergeneeskunde,
Gerard J O'Sullivan, and
Colm M O'Tuathaigh, and
Jeremiah J Clifford, and
Gillian F O'Meara, and
David T Croke, and
John L Waddington
January 1976,
Annual review of microbiology,
Gerard J O'Sullivan, and
Colm M O'Tuathaigh, and
Jeremiah J Clifford, and
Gillian F O'Meara, and
David T Croke, and
John L Waddington
January 2009,
Progress in brain research,
