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The stability of a total nutrient admixture (TNA) has been postulated to be less than 7 days in refrigerated storage. When a TNA destabilizes, lipid particles coalesce and enlarge. Liposomes larger than 6 microns can obstruct pulmonary capillaries. A TNA containing 1500 ml of 7% Vamin, 1000 ml of 50% dextrose and 500 ml of 10% Intralipid, including the usual electrolytes, minerals and vitamins, was studied. Liposome size was measured in the original Intralipid and the TNA at intervals up to 14 days at 4 degrees C followed by 2 days at 22 degrees C. There was a small increase in liposome size up to 16 days. However, the number of particles larger than 6 microns was insignificant (by light microscopy, 3.9 +/- 2.4 [+/- SD] per 20 high-power fields; by Coulter counter, 99.8% smaller than 1.9 microns, with 0% larger than 6 microns; and by electron microscopy, 100% smaller than 2.0 microns). The osmolality and pH of the TNA were 1472 +/- 31 mOsm/kg and 5.5 +/- 0.1 respectively (mean +/- SD), with no significant change during the study times. The authors concluded that this TNA remains physically stable when refrigerated for 14 days and at room temperature for a further 2 days.
M Deitel, and
L C Smith, and
K L Friedman, and
P J Lea, and
D J Grant, and
H K Giang, and
B Calvieri, and
J Go, and
T B To
February 1992,
Journal of the American College of Nutrition,
M Deitel, and
L C Smith, and
K L Friedman, and
P J Lea, and
D J Grant, and
H K Giang, and
B Calvieri, and
J Go, and
T B To
November 2001,
Die Pharmazie,
M Deitel, and
L C Smith, and
K L Friedman, and
P J Lea, and
D J Grant, and
H K Giang, and
B Calvieri, and
J Go, and
T B To
July 1995,
American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists,
M Deitel, and
L C Smith, and
K L Friedman, and
P J Lea, and
D J Grant, and
H K Giang, and
B Calvieri, and
J Go, and
T B To
April 2008,
Vojnosanitetski pregled,
M Deitel, and
L C Smith, and
K L Friedman, and
P J Lea, and
D J Grant, and
H K Giang, and
B Calvieri, and
J Go, and
T B To
October 1985,
American journal of hospital pharmacy,
M Deitel, and
L C Smith, and
K L Friedman, and
P J Lea, and
D J Grant, and
H K Giang, and
B Calvieri, and
J Go, and
T B To
January 1985,
Nutrition reviews,
M Deitel, and
L C Smith, and
K L Friedman, and
P J Lea, and
D J Grant, and
H K Giang, and
B Calvieri, and
J Go, and
T B To
September 1983,
Journal of clinical and hospital pharmacy,
M Deitel, and
L C Smith, and
K L Friedman, and
P J Lea, and
D J Grant, and
H K Giang, and
B Calvieri, and
J Go, and
T B To
March 1990,
DICP : the annals of pharmacotherapy,
M Deitel, and
L C Smith, and
K L Friedman, and
P J Lea, and
D J Grant, and
H K Giang, and
B Calvieri, and
J Go, and
T B To
June 1991,
Zhonghua wai ke za zhi [Chinese journal of surgery],
M Deitel, and
L C Smith, and
K L Friedman, and
P J Lea, and
D J Grant, and
H K Giang, and
B Calvieri, and
J Go, and
T B To
January 1986,
JPEN. Journal of parenteral and enteral nutrition,
