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Despite extensive efforts, little progress has been made in identifying the factors that induce hepatic fibrosis. Transforming growth factor-beta (TGF-beta) has been shown to enhance collagen production, therefore its role in hepatic fibrosis was investigated. Treatment of cultured hepatic cells with TGF-beta 1 increased type I procollagen mRNA levels 13-fold due to post-transcriptional gene regulation. When two animal models of hepatic fibrosis, murine schistosomiasis and CCl4-treated rats, were examined, they both exhibited increased levels of TGF-beta 1 gene expression at times that somewhat preceded the increase in collagen synthesis. In contrast, in murine schistosomiasis, mRNA levels of tumor necrosis factor and interleukin-1 peaked early in the fibrogenic process. Immunohistochemical analysis showed TGF-beta 1 to be present in normal mouse liver and to be markedly increased in mice infected with schistosomiasis. TGF-beta 1 appeared in the hepatic parenchyma, primarily in hepatocytes. These findings strongly suggest a role for TGF-beta 1 in a pathophysiological state.
M J Czaja, and
F R Weiner, and
K C Flanders, and
M A Giambrone, and
R Wind, and
L Biempica, and
M A Zern
January 2002,
International journal of immunopathology and pharmacology,
M J Czaja, and
F R Weiner, and
K C Flanders, and
M A Giambrone, and
R Wind, and
L Biempica, and
M A Zern
February 2004,
European journal of gastroenterology & hepatology,
M J Czaja, and
F R Weiner, and
K C Flanders, and
M A Giambrone, and
R Wind, and
L Biempica, and
M A Zern
September 2022,
Journal of cellular physiology,
M J Czaja, and
F R Weiner, and
K C Flanders, and
M A Giambrone, and
R Wind, and
L Biempica, and
M A Zern
January 2013,
The Journal of pathology,
M J Czaja, and
F R Weiner, and
K C Flanders, and
M A Giambrone, and
R Wind, and
L Biempica, and
M A Zern
June 2007,
World journal of gastroenterology,
M J Czaja, and
F R Weiner, and
K C Flanders, and
M A Giambrone, and
R Wind, and
L Biempica, and
M A Zern
January 1991,
Growth factors (Chur, Switzerland),
M J Czaja, and
F R Weiner, and
K C Flanders, and
M A Giambrone, and
R Wind, and
L Biempica, and
M A Zern
February 2000,
Journal of molecular and cellular cardiology,
M J Czaja, and
F R Weiner, and
K C Flanders, and
M A Giambrone, and
R Wind, and
L Biempica, and
M A Zern
January 2000,
Molecular genetics and metabolism,
M J Czaja, and
F R Weiner, and
K C Flanders, and
M A Giambrone, and
R Wind, and
L Biempica, and
M A Zern
January 1992,
Molecular endocrinology (Baltimore, Md.),
M J Czaja, and
F R Weiner, and
K C Flanders, and
M A Giambrone, and
R Wind, and
L Biempica, and
M A Zern
May 2002,
The American journal of pathology,
