Biomaterial Database

Biological equivalent dose prediction in pion irradiation using pion star density and the mixed beam lesion additivity model. 1989

H Shirato

Cancer Control Agency of British Columbia, Batho Biomedical Facility, TRIUMF, University of British Columbia, Vancouver, Canada.

The biological equivalent dose profile of the pion beam was predicted with one parameter (gamma) using physical dose and pion star density. The value of the relative biological effectiveness (RBE) at each depth was given as a linear function of pion star density (PSD): RBE = 1.0 + gamma PSD, assuming (i) the mixed beam lesion additivity model and (ii) the linear relationship between the ratio of high LET dose to total dose and pion star density. The predicted depth-survival curve fitted well with the pooled biological data of the gel technique using Chinese hamster cells (CHO). The predicted RBE were consistent with previously published results through the flat dose peak, except at the decreasing portion of the dose profile. The practical usefulness of this model in clinical treatment is stressed.

UI	MeSH Term	Description	Entries
D008651	Mesons	Short-lived elementary particles found in cosmic radiation or produced from nuclear disintegration. Their mass is between that of protons and electrons and they can be negative, positive, or neutral. pi-Mesons (pions) are heavier than mu-mesons (muons) and are proposed for cancer radiotherapy because their capture and disintegration by matter produces powerful, but short-lived, secondary radiation.	Muons,Pions,mu-Mesons,pi-Mesons,Meson,Muon,Pion,mu Mesons,mu-Meson,pi Mesons,pi-Meson
D011882	Radiotherapy, High-Energy	Radiotherapy using high-energy (megavolt or higher) ionizing radiation. Types of radiation include gamma rays, produced by a radioisotope within a teletherapy unit; x-rays, electrons, protons, alpha particles (helium ions) and heavy charged ions, produced by particle acceleration; and neutrons and pi-mesons (pions), produced as secondary particles following bombardment of a target with a primary particle.	Megavolt Radiotherapy,High-Energy Radiotherapy,Radiotherapy, Megavolt,High Energy Radiotherapy,Radiotherapy, High Energy
D012062	Relative Biological Effectiveness	The ratio of radiation dosages required to produce identical change based on a formula comparing other types of radiation with that of gamma or roentgen rays.	Biological Effectiveness, Relative,Effectiveness, Biologic Relative,Effectiveness, Biological Relative,Relative Biologic Effectiveness,Biologic Effectiveness, Relative,Biologic Relative Effectiveness,Biological Relative Effectiveness,Effectiveness, Relative Biologic,Effectiveness, Relative Biological,Relative Effectiveness, Biologic
D002470	Cell Survival	The span of viability of a cell characterized by the capacity to perform certain functions such as metabolism, growth, reproduction, some form of responsiveness, and adaptability.	Cell Viability,Cell Viabilities,Survival, Cell,Viabilities, Cell,Viability, Cell
D006224	Cricetinae	A subfamily in the family MURIDAE, comprising the hamsters. Four of the more common genera are Cricetus, CRICETULUS; MESOCRICETUS; and PHODOPUS.	Cricetus,Hamsters,Hamster
D000818	Animals	Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA.	Animal,Metazoa,Animalia
D066298	In Vitro Techniques	Methods to study reactions or processes taking place in an artificial environment outside the living organism.	In Vitro Test,In Vitro Testing,In Vitro Tests,In Vitro as Topic,In Vitro,In Vitro Technique,In Vitro Testings,Technique, In Vitro,Techniques, In Vitro,Test, In Vitro,Testing, In Vitro,Testings, In Vitro,Tests, In Vitro,Vitro Testing, In