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The Opisthorchis viverrini genome provides insights into life in the bile duct. 2014
Neil D Young, and
Niranjan Nagarajan, and
Suling Joyce Lin, and
Pasi K Korhonen, and
Aaron R Jex, and
Ross S Hall, and
Helena Safavi-Hemami, and
Worasak Kaewkong, and
Denis Bertrand, and
Song Gao, and
Qihui Seet, and
Sopit Wongkham, and
Bin Tean Teh, and
Chaisiri Wongkham, and
Pewpan Maleewong Intapan, and
Wanchai Maleewong, and
Xinhua Yang, and
Min Hu, and
Zuo Wang, and
Andreas Hofmann, and
Paul W Sternberg, and
Patrick Tan, and
Jun Wang, and
Robin B Gasser
1] Faculty of Veterinary Science, The University of Melbourne, Melbourne, Victoria 3010, Australia [2].
Opisthorchiasis is a neglected, tropical disease caused by the carcinogenic Asian liver fluke, Opisthorchis viverrini. This hepatobiliary disease is linked to malignant cancer (cholangiocarcinoma, CCA) and affects millions of people in Asia. No vaccine is available, and only one drug (praziquantel) is used against the parasite. Little is known about O. viverrini biology and the diseases that it causes. Here we characterize the draft genome (634.5 Mb) and transcriptomes of O. viverrini, elucidate how this fluke survives in the hostile environment within the bile duct and show that metabolic pathways in the parasite are highly adapted to a lipid-rich diet from bile and/or cholangiocytes. We also provide additional evidence that O. viverrini and other flukes secrete proteins that directly modulate host cell proliferation. Our molecular resources now underpin profound explorations of opisthorchiasis/CCA and the design of new interventions.
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