GABAA receptor agonist at the caudo-lateral peribrachial area suppresses ponto-geniculo-occipital waves and its related states. 2014

Ignacio Ramírez-Salado, and Ana Paula Rivera-García, and Javier Velázquez Moctezuma, and Anabel Jiménez Anguiano, and Francisco Pellicer
Doctorado en Ciencias Biológicas y de la Salud, Universidad Autónoma Metropolitana-Iztapalapa, San Rafael Atlixco 186, Col. Vicentina, Iztapalapa, 09340, Mexico; Laboratorio de Cronobiología, Dirección de Investigaciones en Neurociencias, Instituto Nacional de Psiquiatría "Ramón de la Fuente Muñiz", Calz. México-Xochimilco 101, Col. San Lorenzo Huipulco, Tlalpan, 14370, Mexico. Electronic address: salado@imp.edu.mx.

OBJECTIVE In order to explore the potential role of GABA, acetylcholine and glutamate in the caudo-lateral peribrachial area (C-PBL) over Rapid-Eye-Movement sleep (REM) onset and maintenance as well as on synchronized sleep with ponto-geniculo-occipital (PGO) waves (SP) in cats, a muscimol, carbachol and L-glutamate local application was performed and behavioral states were assessed. METHODS Fourteen chronically implanted, adult, male cats underwent a 23 hour polysomnographic recording after 3 pharmacological manipulations: carbachol, muscimol and L-glutamate. Each cat received all three drugs randomly with a seven day interval. RESULTS 1) Carbachol increases waking, SP and REM sleep while decreases slow wave sleep (SWS). 2) Muscimol decreases SP percentage and number while increases REM sleep onset. 3) Carbachol facilitates PGO activity and increases the latency to both SWS1 and REM sleep but enhances PGO activity while muscimol decreases it. CONCLUSIONS Acetylcholine promotes PGO related states (SP as well as REM sleep), while GABA reduces only SP and specifically PGOs.

UI MeSH Term Description Entries
D008297 Male Males
D008845 Microinjections The injection of very small amounts of fluid, often with the aid of a microscope and microsyringes. Microinjection
D009118 Muscimol A neurotoxic isoxazole isolated from species of AMANITA. It is obtained by decarboxylation of IBOTENIC ACID. Muscimol is a potent agonist of GABA-A RECEPTORS and is used mainly as an experimental tool in animal and tissue studies. Agarin,Pantherine
D011149 Pons The front part of the hindbrain (RHOMBENCEPHALON) that lies between the MEDULLA and the midbrain (MESENCEPHALON) ventral to the cerebellum. It is composed of two parts, the dorsal and the ventral. The pons serves as a relay station for neural pathways between the CEREBELLUM to the CEREBRUM. Pons Varolii,Ponte,Pons Varolius,Pontes,Varolii, Pons,Varolius, Pons
D002217 Carbachol A slowly hydrolyzed CHOLINERGIC AGONIST that acts at both MUSCARINIC RECEPTORS and NICOTINIC RECEPTORS. Carbamylcholine,Carbacholine,Carbamann,Carbamoylcholine,Carbastat,Carbocholine,Carboptic,Doryl,Isopto Carbachol,Jestryl,Miostat,Carbachol, Isopto
D002415 Cats The domestic cat, Felis catus, of the carnivore family FELIDAE, comprising over 30 different breeds. The domestic cat is descended primarily from the wild cat of Africa and extreme southwestern Asia. Though probably present in towns in Palestine as long ago as 7000 years, actual domestication occurred in Egypt about 4000 years ago. (From Walker's Mammals of the World, 6th ed, p801) Felis catus,Felis domesticus,Domestic Cats,Felis domestica,Felis sylvestris catus,Cat,Cat, Domestic,Cats, Domestic,Domestic Cat
D000818 Animals Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA. Animal,Metazoa,Animalia
D012895 Sleep, REM A stage of sleep characterized by rapid movements of the eye and low voltage fast pattern EEG. It is usually associated with dreaming. Fast-Wave Sleep,Paradoxical Sleep,Rapid Eye Movements,Rhombencephalic Sleep,Sleep, Fast-Wave,REM Sleep,Eye Movement, Rapid,Eye Movements, Rapid,Fast Wave Sleep,Movement, Rapid Eye,Movements, Rapid Eye,Rapid Eye Movement,Sleep, Fast Wave,Sleep, Paradoxical,Sleep, Rhombencephalic
D014851 Wakefulness A state in which there is an enhanced potential for sensitivity and an efficient responsiveness to external stimuli. Wakefulnesses
D058785 GABA-A Receptor Agonists Endogenous compounds and drugs that bind to and activate GABA-A RECEPTORS. GABA-A Agonists,GABA-A Receptor Agonist,Agonist, GABA-A Receptor,Agonists, GABA-A,Agonists, GABA-A Receptor,GABA A Agonists,GABA A Receptor Agonist,GABA A Receptor Agonists,Receptor Agonist, GABA-A,Receptor Agonists, GABA-A

Related Publications

Ignacio Ramírez-Salado, and Ana Paula Rivera-García, and Javier Velázquez Moctezuma, and Anabel Jiménez Anguiano, and Francisco Pellicer
August 1995, Neuroscience,
Ignacio Ramírez-Salado, and Ana Paula Rivera-García, and Javier Velázquez Moctezuma, and Anabel Jiménez Anguiano, and Francisco Pellicer
October 1992, Archives italiennes de biologie,
Ignacio Ramírez-Salado, and Ana Paula Rivera-García, and Javier Velázquez Moctezuma, and Anabel Jiménez Anguiano, and Francisco Pellicer
January 1989, Neuroscience,
Ignacio Ramírez-Salado, and Ana Paula Rivera-García, and Javier Velázquez Moctezuma, and Anabel Jiménez Anguiano, and Francisco Pellicer
September 1980, Experimental neurology,
Ignacio Ramírez-Salado, and Ana Paula Rivera-García, and Javier Velázquez Moctezuma, and Anabel Jiménez Anguiano, and Francisco Pellicer
September 2023, Brain sciences,
Ignacio Ramírez-Salado, and Ana Paula Rivera-García, and Javier Velázquez Moctezuma, and Anabel Jiménez Anguiano, and Francisco Pellicer
August 1990, The Journal of neuroscience : the official journal of the Society for Neuroscience,
Ignacio Ramírez-Salado, and Ana Paula Rivera-García, and Javier Velázquez Moctezuma, and Anabel Jiménez Anguiano, and Francisco Pellicer
January 1991, Electroencephalography and clinical neurophysiology,
Ignacio Ramírez-Salado, and Ana Paula Rivera-García, and Javier Velázquez Moctezuma, and Anabel Jiménez Anguiano, and Francisco Pellicer
December 1991, Brain research,
Ignacio Ramírez-Salado, and Ana Paula Rivera-García, and Javier Velázquez Moctezuma, and Anabel Jiménez Anguiano, and Francisco Pellicer
September 1980, Experimental neurology,
Ignacio Ramírez-Salado, and Ana Paula Rivera-García, and Javier Velázquez Moctezuma, and Anabel Jiménez Anguiano, and Francisco Pellicer
November 1988, Brain research,
Copied contents to your clipboard!