-transparent.png){kind=logo}
One hundred infertile patients with laparoscopically confirmed ovarian endometriosis were treated with either intranasal (IN) Buserelin (Hoechst, AG, Frankfurt am Main, West Germany) (300 micrograms three times a day) or subcutaneous (SC) Buserelin implant (6.6 mg Buserelin). Serum estradiol was suppressed in the menopausal range in both groups, but the inhibition of the pituitary ovarian axis appeared more profound and consistent in the SC group than in the IN group. Laparoscopic findings proved that the SC Buserelin emerged superior to the IN Buserelin. Indeed, the score of endometriotic lesions and the ovarian cyst diameter were more reduced in the SC group than in the IN group. Moreover, the histologic study showed a lower incidence of active endometriosis and a lower mitotic index of ovarian endometrial epithelium in the SC group than in the IN group. In conclusion, the release of a gonadotropin-releasing hormone agonist by a biodegradable implant achieved better efficacy in reducing endometriotic lesions than the IN mode of administration.
J Donnez, and
M Nisolle-Pochet, and
F Clerckx-Braun, and
J Sandow, and
F Casanas-Roux
February 1988,
The New England journal of medicine,
J Donnez, and
M Nisolle-Pochet, and
F Clerckx-Braun, and
J Sandow, and
F Casanas-Roux
March 1989,
Fertility and sterility,
J Donnez, and
M Nisolle-Pochet, and
F Clerckx-Braun, and
J Sandow, and
F Casanas-Roux
October 2007,
Reproduction in domestic animals = Zuchthygiene,
J Donnez, and
M Nisolle-Pochet, and
F Clerckx-Braun, and
J Sandow, and
F Casanas-Roux
February 1990,
Journal of the Medical Association of Thailand = Chotmaihet thangphaet,
J Donnez, and
M Nisolle-Pochet, and
F Clerckx-Braun, and
J Sandow, and
F Casanas-Roux
April 1989,
Schweizerische Rundschau fur Medizin Praxis = Revue suisse de medecine Praxis,
J Donnez, and
M Nisolle-Pochet, and
F Clerckx-Braun, and
J Sandow, and
F Casanas-Roux
January 1991,
Zhonghua yi xue za zhi = Chinese medical journal; Free China ed,
J Donnez, and
M Nisolle-Pochet, and
F Clerckx-Braun, and
J Sandow, and
F Casanas-Roux
January 1989,
Zentralblatt fur Gynakologie,
J Donnez, and
M Nisolle-Pochet, and
F Clerckx-Braun, and
J Sandow, and
F Casanas-Roux
January 2020,
Therapeutic advances in endocrinology and metabolism,
J Donnez, and
M Nisolle-Pochet, and
F Clerckx-Braun, and
J Sandow, and
F Casanas-Roux
July 1988,
Hinyokika kiyo. Acta urologica Japonica,
J Donnez, and
M Nisolle-Pochet, and
F Clerckx-Braun, and
J Sandow, and
F Casanas-Roux
September 2009,
Fertility and sterility,
