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We examined toxic effect of PenCB and therapeutic effect of squalane on the gingiva in PenCB poisoned beagle dogs. The results obtained were as follows. 1) PenCB exerted blood level-dependent changes of epithelial cells in which appearance of intracellular vacuoles and swollen mitochondria were observed. 2) Large vacuoles might be caused by degeneration of nerve ending were observed within the supra-basal layers. 3) We could not detect the definitive improvement in the gingiva of the PenCB poisoned beagle dogs followed administration of squalane.
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