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Because there is elevation of pp60c-src activity in breast carcinoma tissue, we analyzed primary breast cancer tissue samples from 30 women to determine whether pp60c-src activity correlated with specific clinical parameters. We found that tumors with a progesterone receptor had higher pp60c-src activity than tumors without such a receptor. But there was no association of pp60c-src activity with the presence of an estrogen receptor or of nodes, or with menopausal status or age. The function of pp60c-src in normal cells and in breast cancer is unknown, as is the significance of our finding of an association of elevated pp60c-src activity and the presence of progesterone receptors.
S Lehrer, and
J O'Shaughnessy, and
H K Song, and
E Levine, and
P Savoretti, and
J Dalton, and
R Lipsztein, and
S Kalnicki, and
W D Bloomer
May 1990,
International journal of cancer,
S Lehrer, and
J O'Shaughnessy, and
H K Song, and
E Levine, and
P Savoretti, and
J Dalton, and
R Lipsztein, and
S Kalnicki, and
W D Bloomer
April 1987,
Proceedings of the National Academy of Sciences of the United States of America,
S Lehrer, and
J O'Shaughnessy, and
H K Song, and
E Levine, and
P Savoretti, and
J Dalton, and
R Lipsztein, and
S Kalnicki, and
W D Bloomer
October 1986,
The Journal of biological chemistry,
S Lehrer, and
J O'Shaughnessy, and
H K Song, and
E Levine, and
P Savoretti, and
J Dalton, and
R Lipsztein, and
S Kalnicki, and
W D Bloomer
July 1990,
Experimental cell research,
S Lehrer, and
J O'Shaughnessy, and
H K Song, and
E Levine, and
P Savoretti, and
J Dalton, and
R Lipsztein, and
S Kalnicki, and
W D Bloomer
June 1990,
European journal of biochemistry,
S Lehrer, and
J O'Shaughnessy, and
H K Song, and
E Levine, and
P Savoretti, and
J Dalton, and
R Lipsztein, and
S Kalnicki, and
W D Bloomer
September 1991,
British journal of cancer,
S Lehrer, and
J O'Shaughnessy, and
H K Song, and
E Levine, and
P Savoretti, and
J Dalton, and
R Lipsztein, and
S Kalnicki, and
W D Bloomer
July 1984,
Developmental biology,
S Lehrer, and
J O'Shaughnessy, and
H K Song, and
E Levine, and
P Savoretti, and
J Dalton, and
R Lipsztein, and
S Kalnicki, and
W D Bloomer
January 1994,
Proceedings of the National Academy of Sciences of the United States of America,
S Lehrer, and
J O'Shaughnessy, and
H K Song, and
E Levine, and
P Savoretti, and
J Dalton, and
R Lipsztein, and
S Kalnicki, and
W D Bloomer
December 1989,
The Journal of biological chemistry,
S Lehrer, and
J O'Shaughnessy, and
H K Song, and
E Levine, and
P Savoretti, and
J Dalton, and
R Lipsztein, and
S Kalnicki, and
W D Bloomer
May 1988,
Biochimica et biophysica acta,
