BIOMAT Database Logo BIOMAT Database Logo

RANK rs1805034 T>C polymorphism is associated with susceptibility of esophageal cancer in a Chinese population. 2014

Jun Yin, and Liming Wang, and Weifeng Tang, and Xu Wang, and Lu Lv, and Aizhong Shao, and Yijun Shi, and Guowen Ding, and Suocheng Chen, and Haiyong Gu
Department of Cardiothoracic Surgery, Affiliated People's Hospital of Jiangsu University, Zhenjiang, China.

Esophageal cancer remains the sixth leading cause of cancer associated death and eighth most common cancer worldwide. Genetic factors, such as single nucleotide polymorphisms (SNPs), may contribute to the carcinogenesis of esophageal cancer. Here, we conducted a hospital based case-control study to evaluate the genetic susceptibility of functional SNPs on the development of esophageal cancer. A total of 629 esophageal squamous cell carcinoma (ESCC) cases and 686 controls were enrolled for this study. The OPG rs3102735 T>C, rs2073618 G>C, RANK rs1805034 T>C, RANKL rs9533156 T>C and rs2277438 A>G were determined by ligation detection reaction method. Our findings suggested that RANK rs1805034 T>C is associated with the susceptibility of ESCC, which is more evident in male and elder (≥63) patients. Our study provides the first evidence that functional polymorphisms RANK rs1805034 T>C may be an indicator for individual susceptibility to ESCC. However, further larger studies among different ethnic populations are warranted to verify our conclusion.

UI MeSH Term Description Entries
D008297 Male Males
D008875 Middle Aged An adult aged 45 - 64 years. Middle Age
D002294 Carcinoma, Squamous Cell A carcinoma derived from stratified SQUAMOUS EPITHELIAL CELLS. It may also occur in sites where glandular or columnar epithelium is normally present. (From Stedman, 25th ed) Carcinoma, Epidermoid,Carcinoma, Planocellular,Carcinoma, Squamous,Squamous Cell Carcinoma,Carcinomas, Epidermoid,Carcinomas, Planocellular,Carcinomas, Squamous,Carcinomas, Squamous Cell,Epidermoid Carcinoma,Epidermoid Carcinomas,Planocellular Carcinoma,Planocellular Carcinomas,Squamous Carcinoma,Squamous Carcinomas,Squamous Cell Carcinomas
D002681 China A country spanning from central Asia to the Pacific Ocean. Inner Mongolia,Manchuria,People's Republic of China,Sinkiang,Mainland China
D004938 Esophageal Neoplasms Tumors or cancer of the ESOPHAGUS. Cancer of Esophagus,Esophageal Cancer,Cancer of the Esophagus,Esophagus Cancer,Esophagus Neoplasm,Neoplasms, Esophageal,Cancer, Esophageal,Cancer, Esophagus,Cancers, Esophageal,Cancers, Esophagus,Esophageal Cancers,Esophageal Neoplasm,Esophagus Cancers,Esophagus Neoplasms,Neoplasm, Esophageal,Neoplasm, Esophagus,Neoplasms, Esophagus
D005260 Female Females
D006801 Humans Members of the species Homo sapiens. Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D000077277 Esophageal Squamous Cell Carcinoma A carcinoma that originates usually from cells on the surface of the middle and lower third of the ESOPHAGUS. Tumor cells exhibit typical squamous morphology and form large polypoid lesions. Mutations in RNF6, LZTS1, TGFBR2, DEC1, and WWOX1 genes are associated with this cancer. Oesophageal Squamous Cell Carcinoma
D000368 Aged A person 65 years of age or older. For a person older than 79 years, AGED, 80 AND OVER is available. Elderly
D016022 Case-Control Studies Comparisons that start with the identification of persons with the disease or outcome of interest and a control (comparison, referent) group without the disease or outcome of interest. The relationship of an attribute is examined by comparing both groups with regard to the frequency or levels of outcome over time. Case-Base Studies,Case-Comparison Studies,Case-Referent Studies,Matched Case-Control Studies,Nested Case-Control Studies,Case Control Studies,Case-Compeer Studies,Case-Referrent Studies,Case Base Studies,Case Comparison Studies,Case Control Study,Case Referent Studies,Case Referrent Studies,Case-Comparison Study,Case-Control Studies, Matched,Case-Control Studies, Nested,Case-Control Study,Case-Control Study, Matched,Case-Control Study, Nested,Case-Referent Study,Case-Referrent Study,Matched Case Control Studies,Matched Case-Control Study,Nested Case Control Studies,Nested Case-Control Study,Studies, Case Control,Studies, Case-Base,Studies, Case-Comparison,Studies, Case-Compeer,Studies, Case-Control,Studies, Case-Referent,Studies, Case-Referrent,Studies, Matched Case-Control,Studies, Nested Case-Control,Study, Case Control,Study, Case-Comparison,Study, Case-Control,Study, Case-Referent,Study, Case-Referrent,Study, Matched Case-Control,Study, Nested Case-Control

Related Publications

Jun Yin, and Liming Wang, and Weifeng Tang, and Xu Wang, and Lu Lv, and Aizhong Shao, and Yijun Shi, and Guowen Ding, and Suocheng Chen, and Haiyong Gu
RANK rs1805034 T>C Polymorphism Is Associated with Susceptibility to Gastric Cardia Adenocarcinoma in a Chinese Population.
January 2015, Oncology research and treatment,
Jun Yin, and Liming Wang, and Weifeng Tang, and Xu Wang, and Lu Lv, and Aizhong Shao, and Yijun Shi, and Guowen Ding, and Suocheng Chen, and Haiyong Gu
The polymorphism of CLOCK gene 3111T/C C>T is associated with susceptibility of Alzheimer disease in Chinese population.
October 2013, Journal of investigative medicine : the official publication of the American Federation for Clinical Research,
Jun Yin, and Liming Wang, and Weifeng Tang, and Xu Wang, and Lu Lv, and Aizhong Shao, and Yijun Shi, and Guowen Ding, and Suocheng Chen, and Haiyong Gu
XPF-673C>T polymorphism effect on the susceptibility to esophageal cancer in Chinese population.
January 2014, PloS one,
Jun Yin, and Liming Wang, and Weifeng Tang, and Xu Wang, and Lu Lv, and Aizhong Shao, and Yijun Shi, and Guowen Ding, and Suocheng Chen, and Haiyong Gu
The polymorphism of ARNTL2 (BMAL2) gene rs2306074 C>T is associated with susceptibility of Alzheimer disease in Chinese population.
November 2014, Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology,
Jun Yin, and Liming Wang, and Weifeng Tang, and Xu Wang, and Lu Lv, and Aizhong Shao, and Yijun Shi, and Guowen Ding, and Suocheng Chen, and Haiyong Gu
ABCC1 polymorphism Arg723Gln (2168G> A) is associated with lung cancer susceptibility in a Chinese population.
September 2011, Clinical and experimental pharmacology & physiology,
Jun Yin, and Liming Wang, and Weifeng Tang, and Xu Wang, and Lu Lv, and Aizhong Shao, and Yijun Shi, and Guowen Ding, and Suocheng Chen, and Haiyong Gu
[Genetic polymorphism in MDM2 is associated with susceptibility to colorectal cancer in a Chinese population].
May 2008, Zhonghua zhong liu za zhi [Chinese journal of oncology],
Jun Yin, and Liming Wang, and Weifeng Tang, and Xu Wang, and Lu Lv, and Aizhong Shao, and Yijun Shi, and Guowen Ding, and Suocheng Chen, and Haiyong Gu
PTPN22 -1123G > C polymorphism is associated with susceptibility to primary immune thrombocytopenia in Chinese population.
January 2013, Platelets,
Jun Yin, and Liming Wang, and Weifeng Tang, and Xu Wang, and Lu Lv, and Aizhong Shao, and Yijun Shi, and Guowen Ding, and Suocheng Chen, and Haiyong Gu
[p53 gene polymorphism with susceptibility to esophageal cancer and lung cancer in Chinese population].
July 2003, Zhonghua zhong liu za zhi [Chinese journal of oncology],
Jun Yin, and Liming Wang, and Weifeng Tang, and Xu Wang, and Lu Lv, and Aizhong Shao, and Yijun Shi, and Guowen Ding, and Suocheng Chen, and Haiyong Gu
Polymorphism rs2682818 in miR-618 is associated with colorectal cancer susceptibility in a Han Chinese population.
April 2018, Cancer medicine,
Jun Yin, and Liming Wang, and Weifeng Tang, and Xu Wang, and Lu Lv, and Aizhong Shao, and Yijun Shi, and Guowen Ding, and Suocheng Chen, and Haiyong Gu
HOTAIR rs920778 polymorphism is associated with ovarian cancer susceptibility and poor prognosis in a Chinese population.
February 2017, Future oncology (London, England),
Copied contents to your clipboard!