Neopterin concentrations in cerebrospinal fluid and serum of individuals infected with HIV-1. 1989

D Fuchs, and F Chiodi, and J Albert, and B Asjö, and L Hagberg, and A Hausen, and G Norkrans, and G Reibnegger, and E R Werner, and H Wachter
Institute of Medical Chemistry and Biochemistry, University of Innsbruck, Austria.

Neopterin, a biochemical marker for the activation of cell-mediated immune reactions, was determined in serum and cerebrospinal fluid (CSF) from patients infected with HIV-1. A significant correlation was found between serum and CSF neopterin concentrations, although concentrations of neopterin in serum were more closely correlated with the clinical severity of HIV-1 infection than those in CSF. However, higher CSF levels were observed in patients with neurologic/psychiatric symptoms than in unaffected patients. Also, quotients of CSF neopterin versus serum neopterin concentrations were increased, indicating intrathecal production of neopterin. Positive HIV-1 isolation from peripheral blood mononuclear cells (PBMC) was associated with higher neopterin concentrations in serum, when compared with negative HIV-1 isolation. Neopterin in CSF appears to be a suitable biochemical marker in patients with HIV-1 infection for detecting overt neurologic/psychiatric disturbances. The data suggest that in HIV-1 infected patients, cell-mediated immune reactions might be activated intrathecally and might contribute to neuropsychiatric disease.

UI MeSH Term Description Entries
D008297 Male Males
D008875 Middle Aged An adult aged 45 - 64 years. Middle Age
D009422 Nervous System Diseases Diseases of the central and peripheral nervous system. This includes disorders of the brain, spinal cord, cranial nerves, peripheral nerves, nerve roots, autonomic nervous system, neuromuscular junction, and muscle. Neurologic Disorders,Nervous System Disorders,Neurological Disorders,Disease, Nervous System,Diseases, Nervous System,Disorder, Nervous System,Disorder, Neurologic,Disorder, Neurological,Disorders, Nervous System,Disorders, Neurologic,Disorders, Neurological,Nervous System Disease,Nervous System Disorder,Neurologic Disorder,Neurological Disorder
D003704 Dementia An acquired organic mental disorder with loss of intellectual abilities of sufficient severity to interfere with social or occupational functioning. The dysfunction is multifaceted and involves memory, behavior, personality, judgment, attention, spatial relations, language, abstract thought, and other executive functions. The intellectual decline is usually progressive, and initially spares the level of consciousness. Senile Paranoid Dementia,Amentia,Familial Dementia,Amentias,Dementia, Familial,Dementias,Dementias, Familial,Dementias, Senile Paranoid,Familial Dementias,Paranoid Dementia, Senile,Paranoid Dementias, Senile,Senile Paranoid Dementias
D005260 Female Females
D006801 Humans Members of the species Homo sapiens. Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D000163 Acquired Immunodeficiency Syndrome An acquired defect of cellular immunity associated with infection by the human immunodeficiency virus (HIV), a CD4-positive T-lymphocyte count under 200 cells/microliter or less than 14% of total lymphocytes, and increased susceptibility to opportunistic infections and malignant neoplasms. Clinical manifestations also include emaciation (wasting) and dementia. These elements reflect criteria for AIDS as defined by the CDC in 1993. AIDS,Immunodeficiency Syndrome, Acquired,Immunologic Deficiency Syndrome, Acquired,Acquired Immune Deficiency Syndrome,Acquired Immuno-Deficiency Syndrome,Acquired Immuno Deficiency Syndrome,Acquired Immuno-Deficiency Syndromes,Acquired Immunodeficiency Syndromes,Immuno-Deficiency Syndrome, Acquired,Immuno-Deficiency Syndromes, Acquired,Immunodeficiency Syndromes, Acquired,Syndrome, Acquired Immuno-Deficiency,Syndrome, Acquired Immunodeficiency,Syndromes, Acquired Immuno-Deficiency,Syndromes, Acquired Immunodeficiency
D000328 Adult A person having attained full growth or maturity. Adults are of 19 through 44 years of age. For a person between 19 and 24 years of age, YOUNG ADULT is available. Adults
D000368 Aged A person 65 years of age or older. For a person older than 79 years, AGED, 80 AND OVER is available. Elderly
D001708 Biopterins Pterin derivatives based on 2-amino-6-(1,2-dihydroxypropyl)-4(1H)-pteridinone. Biopterins are natural products that have been considered as growth factors for some insects. Biopterins are cofactors for the AROMATIC AMINO ACID hydroxylases and NITRIC OXIDE SYNTHASE. Deficiencies in BIOPTERINS metabolism (e.g., lowered TETRAHYDROBIOPTERIN) are associated with neurological deterioration (e.g., HYPERPHENYLALANINAEMIA). 2-Amino-6-((1S,2R)-1,2-dihydroxypropyl)-4(1H)-pteridinone,2-Amino-6-((1S,2S)-1,2-dihydroxypropyl)-4(1H)-pteridinone,2-Amino-6-(1,2-dihydroxypropyl)-4(8H)-pteridinone,2-amino-6-((1R,2R)-1,2-dihydroxypropyl)-4(3H)-pteridinone,4(1H)-Pteridinone, 2-amino-6-(1,2-dihydroxypropyl)-, (S-(R*,S*))-,6-Biopterin,Biopterin,D-threo-Biopterin,L-Biopterin,L-erythro-Biopterin,L-threo-Biopterin,2-Amino-6-(1,2-dihydroxypropyl)-4(1H)-pteridinone,Dictyopterin,Orinapterin,6 Biopterin,D threo Biopterin,L Biopterin,L erythro Biopterin,L threo Biopterin

Related Publications

D Fuchs, and F Chiodi, and J Albert, and B Asjö, and L Hagberg, and A Hausen, and G Norkrans, and G Reibnegger, and E R Werner, and H Wachter
May 1992, Journal of neurology,
D Fuchs, and F Chiodi, and J Albert, and B Asjö, and L Hagberg, and A Hausen, and G Norkrans, and G Reibnegger, and E R Werner, and H Wachter
April 2009, AIDS research and human retroviruses,
D Fuchs, and F Chiodi, and J Albert, and B Asjö, and L Hagberg, and A Hausen, and G Norkrans, and G Reibnegger, and E R Werner, and H Wachter
December 2001, Journal of neurovirology,
D Fuchs, and F Chiodi, and J Albert, and B Asjö, and L Hagberg, and A Hausen, and G Norkrans, and G Reibnegger, and E R Werner, and H Wachter
November 2009, AIDS (London, England),
D Fuchs, and F Chiodi, and J Albert, and B Asjö, and L Hagberg, and A Hausen, and G Norkrans, and G Reibnegger, and E R Werner, and H Wachter
February 1990, Acta neurologica,
D Fuchs, and F Chiodi, and J Albert, and B Asjö, and L Hagberg, and A Hausen, and G Norkrans, and G Reibnegger, and E R Werner, and H Wachter
December 1991, AIDS (London, England),
D Fuchs, and F Chiodi, and J Albert, and B Asjö, and L Hagberg, and A Hausen, and G Norkrans, and G Reibnegger, and E R Werner, and H Wachter
March 1998, AIDS (London, England),
D Fuchs, and F Chiodi, and J Albert, and B Asjö, and L Hagberg, and A Hausen, and G Norkrans, and G Reibnegger, and E R Werner, and H Wachter
December 2000, Journal of acquired immune deficiency syndromes (1999),
D Fuchs, and F Chiodi, and J Albert, and B Asjö, and L Hagberg, and A Hausen, and G Norkrans, and G Reibnegger, and E R Werner, and H Wachter
September 1992, Journal of neuroimmunology,
D Fuchs, and F Chiodi, and J Albert, and B Asjö, and L Hagberg, and A Hausen, and G Norkrans, and G Reibnegger, and E R Werner, and H Wachter
December 2010, Journal of acquired immune deficiency syndromes (1999),
Copied contents to your clipboard!